in the 20th century, an unprecedented level of international cooperation led to the eradication of smallpox, infamously referred to as the most terrible ministers of death. under the guardianship of the world health organisation, mass vaccination campaigns and an efficient surveillance-detection system contributed to the eradication of smallpox from bahrain, where it was once considered endemic...

This report outlines recommendations for the clinical use of the three smallpox vaccines stored in the U.S. Strategic National Stockpile for persons who are exposed to smallpox virus or at high risk for smallpox infection during a postevent vaccination program following an intentional or accidental release of the virus. No absolute contraindications exist for smallpox vaccination in a postevent...

INTRODUCTION Should the general population be vaccinated against smallpox (Variola Major)? Would the benefits of mass vaccination outweigh the risks? How many deaths would occur as the result of a mass vaccination campaign against smallpox? Can mathematical models of smallpox vaccination be used to determine health policy? Although smallpox was declared eradicated by the World Health Organizati...

Smallpox was probably the single most lethal disease in eighteenth-century Britain but was reduced to a minor cause of death by the mid-nineteenth century due to vaccination programmes post-1798.While the success of vaccination is unquestionable, it remains disputed to what extent the prophylactic precursor of vaccination, inoculation, reduced smallpox mortality in the eighteenth century. Small...

After the recent summary of World Health Organization-authorized research on smallpox, several clinical issues remain. This policy review addresses whether early hemorrhagic smallpox is disseminated intravascular coagulation and speculates about the cause of the high mortality rate among pregnant women and whether ocular smallpox is partly the result of trachoma or vitamin A deficiency. The joi...

Smallpox was probably the single most lethal disease in eighteenth century Britain, but was a minor cause of death by the mid-nineteenth century. Although vaccination was crucial to the decline of smallpox especially in urban areas from the beginning of the nineteenth century, it remains disputed the extent to which smallpox mortality declined before vaccination. Analysis of age-specific change...

Foege, W. H., J. D. Millar and J. M. Lane (CDC, Atlanta, Ga. 30333). Selective epidemiologic control in smallpox eradication. Amer J Epidem 94: 311-315, 1971.—A change of strategy was instituted in the West and Central Africa Smallpox Eradication Program in the fall of 1968. High priority was given to eliminating smallpox foci rather than limiting activities to mass vaccination. The progress of...