Malignant transformation of cells into cancer arises due to long term accumulation of genetic and epigenetic events. Early diagnosis of these transformations in cells can improve the prognosis of cancer cases. Cancer screening and surveillance methods include ultrasound, mammography, digital mammography, magnetic resonance imaging, computed tomography, positron emission tomography and magnetic ...

Diabetes mellitus is a heterogeneous group of disorders, in which hyperglycemia is a main feature. The objective was to evaluate the involvement of RAGE, inflammatory cytokines, and metalloproteinases in spontaneous periodontitis triggered by diabetes induction. Immunohistochemical procedures for MMP-2, MMP-9, TNF-α, IL-1β, IL-6, RANKL, and RAGE were performed in rats after 1, 3, 6, 9, and 12 m...

OBJECTIVE To extend the molecular analysis of the IVS30+1G>T intronic thyroglobulin (TG) mutation, and to report the eleven year follow-up of the affected patients. METHOSD: Two siblings with severe congenital hypothyroidism with fetal and neonatal goiter, harboring the IVS30+1G>T mutation were included. Nodular and non-nodular thyroid tissue specimens were collected. Specific thyroid genes exp...

Purpose: This study was conducted to explore the differences in salivary microRNA (miRNA) profiles between patients withmalignant or benign parotid gland tumors as a potential preoperative diagnostic tool of tumors in the salivary glands. Experimental Design:Whole saliva samples from patients with malignant (n1⁄4 38) or benign (n1⁄4 29) parotid gland tumors were obtained from the Salivary Gland...

Purpose: This study was conducted to explore the differences in salivary microRNA (miRNA) profiles between patients withmalignant or benign parotid gland tumors as a potential preoperative diagnostic tool of tumors in the salivary glands. Experimental Design:Whole saliva samples from patients with malignant (n1⁄4 38) or benign (n1⁄4 29) parotid gland tumors were obtained from the Salivary Gland...

Background: Decoy receptor 3 (DcR3), a decoy receptor against Fas ligand belonging to the tumor necrosis factor receptor super-family, is over-expressed in types of tumor. The aim of this study was to explore the expression level of DcR3 and investigated its diagnostic value in colorectal cancer (CRC). Methods: Quantitative Real-timePCR (qRT-PCR) and western blot were performed to determine the...