نتایج جستجو برای: transcriptional targeting
تعداد نتایج: 260708 فیلتر نتایج به سال:
objective: the greatest challenge in cancer gene therapy is to achieve the high specificity and efficiency in targeting of cancer cells. because the goal of cancer gene therapy is to eradicate cancer cells, many therapeutic genes could be detrimental if unintentionally expressed in normal cells. using promoter of the genes which are expressed specifically in cancer cells or have much more expre...
In this issue of Blood, Xu et al report on a novel regulator red cell differentiation, F-box only protein 11 (FBXO11), that removes transcriptional repressors from erythroid genes releasing their expression by targeting the chromatin-associated bromo adjacent homology domain–containing 1 (BAHD1) for degradation.1
Background and purpose: Interest into targeting PI3K in cancer has increased by the recent disclosure that aberrant activity of PI3K/Akt signaling pathway is associated with disease recurrence and poor outcome in different malignancies. The aim of this study was to investigate the potentiating effect of PI3K inhibitor, GS-1101 on doxorubicin-induced cell death in acute lymphoblastic leukemia-de...
Thyroid cancer, which is known as the most common type of endocrine cancer, has seen a growing prevalence in the last few years. On the other hand, only a small percentage of them are associated with malignancy and most of them are benign tumors. Therefore, the first step in the proper management of this type of cancer is to distinguish malignant tumors from benign ones, and today, we are tryin...
The link between a growing number of human diseases and misregulation of gene expression has spurred intense interest in artificial transcriptional activators that could be used to restore controlled expression of affected genes. To expand the repertoire of activation domains available for the construction of artificial transcriptional regulators, a selection strategy was used to identify two u...
Background and purpose: Telomerase activity has a major role in acute promyelocytic leukemia (APL). It also has a critical role in disease recurrence. This research aimed at studying the cytotoxic effects of telomerase inhibition using oligonucleotide-based molecule against human telomerase RNA template (hTERC antisense) and non-nucleoside small molecule targeting catalytic subunit (BIBR5132) o...
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