in this study, the essential oil obtained by hydrodistillation of the seeds of vitex pseudo-negundo (verbenaceae), growing wild in sabzevar, khorasan razavi province, iran, were analyzed by gc and gc/ms. the yield of total volatiles was 0.8% (w/w). thirty-seven compounds representing 92.4% of the seed oil were identified. the main components of the oil were hexadecanoic acid (8.0%), elemol (7.0...

Resume of 'previous work.?Vaughan (1921) found that an aqueous infusion of the leaves of Vitex peduncularis, Wall, var. roxburghiana, was being used by the aboriginal tribe of Ranchi in malaria and blackwater fever. Though the medicinal properties of the members of the Vitex family (e.g. Vitex trifolia, negundo, etc.) have been elaborately described in the Ayurvedic system of medicine, the Vite...

An extract from ripe fruit of Vitex agnus-castus (Vitex) has been used to treat patients with various obstetric and gynecological disorders in Europe. We have demonstrated that Vitex showed cytocidal effects on various types of cancer cell lines including a human colon carcinoma cell line, COLO 201. In this study, we extended our previous study to investigate the detailed mechanisms underlying ...

BACKGROUND Aging is associated with the loss of endocrine function. In this study, Vitex agnus-castus (Vitex), which has antioxidant effects and high levels of phytoestrogen, was investigated with regard to the hypothalamic-pituitary-gonadal axis and antioxidant indices in natural aging and in a d-galactose induced aging model in female mice. METHODS The mice were subcutaneously injected with...

We have demonstrated that an extract from the ripe fruit of Vitex agnus-castus (Vitex) exhibits cytotoxic activities against various types of solid tumor cells, whereas its effects on leukemia cells has not been evaluated to date. In this study, the effects of Vitex and its major component, casticin, on leukemia cell lines, HL-60 and U-937, were investigated by focusing on proliferation, induct...