Radioprotective Efficacy of Lutein in Ameliorating Electron Beam Radiation-induced Oxidative Injury in Swiss Albino Mice
Background: Lutein, a carotenoid compound, has previously been studied for its antioxidant and medicinal properties as well as the moderate protection it confers against gamma radiation. This study aimed at evaluating the effects of lutein against radiation-induced hematological and biochemical changes in mice.Methods: The optimized dose of the compound was orally administered for 15 days, and the mice were irradiated (6 Gy) on day 15 after the administration of the compound. The groups were divided (6 mice in each group) into normal control, radiation control, gallic acid control, 10% DMSO control, lutein control, and irradiated groups pretreated with gallic acid, 10% DMSO, and lutein. Gallic acid was used to maintain a standard since it is a proven radioprotector. Within 24 hours post irradiation, the animals were anesthetized and sacrificed. The hematological, biochemical, and antioxidant changes were determined using suitable methods. Data were analyzed by the Kaplan–Meier curve (log-rank test) and ANOVA (the Tukey test). The independent t test was used to compare the independent groups. SPSS (ver. 16) was employed. Results: Maximum survival was observed with a dose of 250 mg/kg b.wt lutein. The total leukocyte count and the percentage lymphocyte count exhibited a significant decline in the irradiated groups pretreated with gallic acid and lutein in comparison to their controls, whereas the percentage granulocyte count showed a significant rise. Antioxidant activity had markedly declined in the irradiated groups, indicating oxidative stress. Lutein pretreatment reduced the damage and maintained the antioxidant system.Conclusion: The present study suggests a protective role for lutein in palliating radiation-induced oxidative changes and maintaining the antioxidant system in vivo.
Radioprotective and antioxidant potential of Tanacetum parthenium extract and synthetic parthenolide in Swiss albino mice exposed to electron beam irradiation
Background: The herb feverfew (Tanacetum parthenium L., Asteraceae) has an ancient reputation as an effective anti-inflammatory, analgesic, antipyretic, and anti-asthmatic agent. Parthenolide a gemacranolide-type sesquiterpene lactone is the major constituent of European feverfew. Materials and Methods: The present study was intended to evaluate the in vivo antioxidant potential and radioprotec...متن کامل
Background: The increasing use of nuclear radiation for human welfare necessitates the search for new, safe, cost effective radio protectors not only for the personnel’s charged with the responsibility of working or testing with radiations in laboratories, but also for general public. With this view the present study has been undertaken to determine the deleterious effects of sub lethal g...متن کامل
Radioprotective Capactivity of Emblica Officinalis against Radiation Induced Biochemical Alterations in Liver of Swiss Albino Mice
Radio protective effect of fruit extract of Emblica officinalis (EO) has been studied against lethal dose (7.5 Gy) of gamma radiation in the liver of Swiss albino mice at various post-irradiation intervals viz. 12 hrs, 24 hrs and 3rd, 5th, 10th,20th and 30th days. In control animals (without EO treated irradiated), an elevation in glycogen and protein content was found till day 3rd and 5th resp...متن کامل
Background: The radioprotective effect of Grewia asiatica fruit (GAE) which contains anthocyanin type cyanidin 3- glucoside, vitamin C, A, minerals, carotenes and dietary fibers etc was studied. Materials and Methods: For study Swiss albino mice were divided into five groups-1. Control (vehicle treated) 2. GAE treated (700 mg / Kg. b.wt / day for fifteen days), 3. Irradiated (5 Gy), 4. G...متن کامل
Background: From the time immemorial man has been exposed to ionizing radiation from the environment in which he lives. Radiation protection concepts and philosophy have been evolving over the past several decades. Materials and Methods: The radioprotective of effect of Aloe vera leaf extract (1000 mg /kg b.wt. orally for 15 consecutive days) has been studied against 6 Gy of gamma radiation in ...متن کامل
دوره 43 شماره 1
صفحات 41- 51
تاریخ انتشار 2018-01-01
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