Fifty-six surgical specimens with various ulcerative intestinal disorders were microscopically investigated for evidence of gastric gland metaplasia. Thiry-one specimens (55-4%) showed pyloric gland metaplasia. Among the 31 patients with pyloric gland metaplasia, five showed true gastric metaplasia, consisting of parietal cells, chief cells, and mucous neck cells. The percentage of true gastric...

THE ARTICLE BY CAROLINA MALAGELADA and colleagues in Barcelona entitled “Classification of functional bowel disorders by objective physiological criteria based on endoluminal image analysis” represents an important advance in the measurement of small intestinal motor functions (5). This novel approach involves novel imaging, combinations of physics and mathematics, as well as gastrointestinal p...

Gut microbiota is key to the development and modulation of the mucosal immune system. It plays a central role in several physiological functions, in the modulation of inflammatory signaling and in the protection against infections. In healthy states, there is a perfect balance between commensal and pathogens, and microbiota and the immune system interact to maintain gut homeostasis. The alterat...

Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a highly conserved energy sensor, has a crucial role in cardiovascular, neurodegenerative and inflammatory diseases, as well as in cancer and metabolic disorders. Accumulating studies have demonstrated that AMPK activation enhances paracellular junctions, nutrient transporters, autophagy and apoptosis, and suppresses inflammation an...

Coronaviruses are known can cause a significant impact on veterinary medicine and socio-economic. Understanding the biological characteristics dynamics of pathogenic coronaviruses is major scientific challenge with potential impacts animal health. typically to respiratory or enteric diseases in poultry pigs. However, some coronavirus strains may extra-pulmonary extra-intestinal disorders. Keepi...

A large and growing body of research implicates aberrant immune response and compositional shifts of the intestinal microbiota in the pathogenesis of many intestinal disorders. The molecular and physical interaction between the host and the microbiota, known as the host-microbiota interactome, is one of the key drivers in the pathophysiology of many of these disorders. This host-microbiota inte...

INTRODUCTION Two decades ago tropical sprue, Immunoproliferative Small Intestinal Disease (IPSID) and infections were common causes of malabsorption in India. It is possible that implementation of preventive health measures and improved sanitation may have changed the spectrum of disorders causing malabsorption. The aim of this study therefore was to assess the spectrum of malabsorption seen at...