BACKGROUND Standards for the reporting of factorial randomised trials remain to be established. We aimed to review the quality of reporting of methodological aspects of published factorial trials of complex interventions in community settings. METHODS We searched MEDLINE, EMBASE, PsychInfo and the Cochrane Controlled Trials Register to identify factorial randomised trials of complex intervent...

Non-regular two-level fractional factorial designs, such as Plackett–Burman designs, are becoming popular choices in many areas of scientific investigation due to their run size economy and flexibility. The run size of nonregular two-level factorial designs is a multiple of 4. They fill the gaps left by the regular twolevel fractional factorial designs whose run size is always a power of 2 (4, ...

The challenge in developing oral drug delivery systems of poorly soluble basic drugs is primarily due to their pH dependent solubility. Cinnarizine (CNZ), a model for a poorly soluble basic drug, has pH dependent solubility; where it dissolves readily at low pH in the stomach and exhibits a very low solubility at pH values greater than 4. It is also characterized by a short half life of 3-6h, w...

the present study was aimed to develop and validate a high performace liquid chromatography method for determination of thiocolchicoside and dexketoprofen trometamol in combined dosage form. the proposed hplc method utilizes an agilent eclipse c-8 column (5 µm, 250×4.6 mm) at ambient temperature. a 23 full factorial design was performed for optimization of mobile phase for separation of two dru...

in order to enhance in vitro dissolution and content uniformity of poorly soluble drug glimepiride by preparing solid dispersions using modified solvent fusion method, solid dispersions of drug were prepared by modified fusion solvent method using peg 6000 and pvp k25 (as carrier). eight batches (f1-f8) were prepared by factorial design (23) by taking three factors i.e. the concentration of: dr...