BACKGROUND A number of anaemic cancer patients are not responsive to treatment with recombinant human erythropoietin (rHuEPO). The aim of the present study is to investigate whether serum levels of tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-1beta, IL-6 and additional laboratory parameters, together with clinical variables, can predict the clinical outcome of treatment with rHuEP...

The purpose of this study was to evaluate the sonographic features of thyroid nodules suspicious for malignancy with standard examination in B-mode and Color Doppler associated with modern techniques such as ultrasound RTE (Real Time Elastosonography) and BFI (B-flow imaging) in correlation with the results of the sonographically guided fine-needle aspiration to establish their role in predicti...

BACKGROUND While opioids provide effective analgesia, opioid-induced constipation (OIC) can severely impact quality of life and treatment compliance. This pooled analysis evaluated the maintenance of efficacy and safety during long-term treatment with combined oxycodone/naloxone prolonged-release tablets (OXN PR) in adults with moderate-to-severe chronic pain. METHODS Patients (N = 474) recei...

Several measures were developed in the past decades to measure personality, focusing on Big Five Factor Model (BFFM; Openness, Conscientiousness, Extraversion, Agreeableness, and Neuroticism). Despite relevance of their findings different countries, a shared limitation such is length, demanding time from researchers participants, which might cause boredom or fatigue, biasing final results. This...

We simultaneously assessed the blood flow index (BFI) in three respiratory muscles during hyperpnea and high-intensity constant-load cycling sustained at comparable levels of work breathing neural drive patients with COPD. demonstrated that exercise impairs muscle perfusion, as intercostal, scalene, abdominal BFI increased but not cycling. Insufficient adjustment perfusion was associated greate...