We present here the results of water restriction test (WRT) and hypertonic saline loading test (HSLT) in normal children. Maximal urine osmolality during WRT (W-Umax; 1040•}154mOsm/kg) may be age-dependent (W-Umax=812+23*age,r=0.52,p<0.05), although maximal arginine vasopressin (AVP) levels during WRT did not show any correlation with age. The relationship between plasma osmolality (Posm) and A...

Three experiments involving 304 pigs were conducted to determine the related effects of copper (Cu), calcium (Ca) and phosphorus (P) on the performance and liver Cu stores of growing-f'mishing pigs. Rate and efficiency of gain were improved by the addition of 250 ppm of Cu to the diets. Improvements in rate of gain averaged 6.6% (652 vs 696 g/d) to 60.5 kg body weight and 1.7% (713 vs 725 g/d) ...

NCX-701 is a nitric oxide (NO)-releasing acetaminophen (APAP) derivative. In the present study we demonstrated that NCX-701 is as effective as APAP in controlling body temperature in a rat model of endotoxin-induced fever. Liver toxicity is a major complication of APAP overdosing. To investigate whether NCX-701 is hepatotoxic, BALB/C mice were injected with 100 - 500 mg kg(-1) APAP or NCX-701 a...

Oligonucleotide probes that can be used for non-denaturing fluorescence in situ hybridization (ND-FISH) analysis are convenient tools for identifying chromosomes of wheat (Triticum aestivum L.) and its relatives. New oligonucleotide probes, Oligo-HvT01, Oligo-pTa71-1, Oligo-s120.1, Oligo-s120.2, Oligo-s120.3, Oligo-275.1, Oligo-275.2, Oligo-k566 and Oligo-713, were designed based on the repetit...

Virulent Helicobacter pylori strains that specifically activate signaling in epithelial cells via the innate immune molecule, nucleotide oligomerization domain 1 (NOD1), are more frequently associated with IFN-γ-dependent inflammation and with severe clinical outcomes (i.e., gastric cancer and peptic ulceration). In cell culture models, we showed that H. pylori activation of the NOD1 pathway ca...

Abstract Recurrent glioblastoma (GBM) is an aggressive disease with poor survival and limited treatment options. SL-701 a novel immunotherapy comprised of synthetic peptides designed to elicit anti-tumor immune response against GBM antigens IL-13Rα2, ephrinA2, survivin. Here we describe 18-color flow cytometry analysis from stage 2 Ph2 clinical trial SL-701+poly-ICLC+bevacizumab (NCT02078648), ...

Precancerous cells that enter S phase without appropriate growth and viability factors undergo programmed cell death, suggesting that apoptosis may help guarantee organismic integrity [Evan, G. & Littlewood, T. (1998) Science 281, 1317-1322]. However, the connection between proliferation and cell death has remained unclear. Here, we show that the positive cell cycle regulator cyclin D3 [Matsush...