نتایج جستجو برای: cdna synthesis and real
تعداد نتایج: 16967463 فیلتر نتایج به سال:
Background:Dysregulation of HOX Transcript Antisense Intergenic RNA (HOTAIR) has been linked to the etiopathogenesis of several human cancers. According to epidemiological evidences, the risk of susceptibility to breast cancer varies among different populations. This study was designed to determine the transcriptional level of HOTAIR in tumor cells of breast cancer pat...
هدف تحقیق: بررسی بیان ایزوفرم های ژن ppar ?در سلول های بنیادی جنینی موش طی تمایز عصبی می باشد. روش تحقیق: ابتدا توسط نرم افزار beacon designer پرایمر های مناسب برای real time pcr تهیه شد. در ادامه کارایی پرایمرهای طراحی شده تعیین شد. سلول های بنیادی جنینی موش د رحضور رتینوئیک اسید (ra) به سمت عصب تمایز داده شد و در سه مرحله سلول های بنیادی جنینی (esc) ، اجسام شبه جنینی تیمار شده با رتینوئیک...
Introduction: One of the complications of diabetes mellitus is induction of apoptosis in liver tissues. Activation of caspase 3 caused apoptosis in the cells. Garlic is a most common plant in diet that its effect on apoptosis was not determined. In this study the effects of this extract on Bax and Bcl-2 gene expression and the activity of caspase 3, were determined in type 1 and 2 of diabetes i...
Abstract Background and Objectives Hepatitis C virus is the main cause of hepatitis C infection that usually has no symptoms at early stages. Studies have shown changes in the expression level of microRNAs in various diseases such as hepatitis. MiR-199a and miR-196b have an inhibitory effect on hepatitis C virus. In a recent study, we examined the expression levels of miR-199a and miR-196b in ...
Background and objectives: Deregulation in the expression of microRNAs is involved in the pathogenesis of various malignancies. Impaired microRNAs processing pathway is one possible mechanism for global deregulation of the miRNAs. Exportin 5 (XPO5) is a key member of this pathway that links nuclear and cytoplasmic steps of miRNAs biogenesis together. XPO5 deregulation has been reported in ...
Background and purpose: Recent studies reported that not only the quantity, but also the quality of dietary fatty acids can affect lipid parameters. Elaidic acid as one of the most important by-product of partially hydrogenated vegetable oil, participate in the development of cardiovascular diseases, especially atherosclerosis through changing in lipid profile and exacerbation of inflammation a...
Introduction: Microglia, small glial cells, i.e. mesodermal in origin and found in the brain and spinal cord, play a key role in the maintenance of neurons and immune defense. Haloperidol, an antipsychotic drug, is used to treat numerous neurological and neurodegenerative disorders. Its mechanism is not understood; however, haloperidol may result in Wnt signaling pathway activation. This study ...
The current study is focused on determining the mRNA expression levels of tetranectin, to detect oral squamous cell carcinoma (OSCC) and thus aiding in its classification at an early stage. RNA was isolated and cDNA synthesis was performed from the saliva samples of the patients and healthy individuals. A semiquantitative PCR based analysis was performed prior to quantitative and expression bas...
objective: animal model studies have shown that msy2 and jhdm2a genes have an important role in spermatogenesis process and fertility of male mice. but the potential role of these genes in human spermatogenesis and fertility is not known yet. therefore, we evaluated expression ratios of these genes in testis tissues of men with normal and impaired spermatogenesis. materials and methods: in this...
Background: Apoptosis is an essential physiological process to maintain immune homeostasis. T-cell incorrect apoptosis appears to be involved in chronic inflammatory diseases such as inflammatory bowel disease (IBD). The aim of this study was to evaluate the Bcl2/BAX genes expression ratio in patients with IBD (Crohn’s disease and ulcerative colitis) compared to healthy persons. Materials and M...
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