OBJECTIVE The objective of this study is to review the main investigations into the secondary effects of the antihistamine chlorpheniramine on the central nervous system (CNS). DEVELOPMENT The antagonists of the H1 receptors of histamine, usually used in the treatment of symptoms of allergy or the common cold, have many adverse effects on the CNS. They cause day time drowsiness, cause poorer ...

AIM Emerging research indicates that gene mutations within the RAS-MAPK signaling cascade, which cause Noonan syndrome and related disorders, affect neurophysiologic activity in brain regions underlying attention and executive functions. The present study examined whether children with Noonan syndrome are at heightened risk for symptoms of attention-deficit-hyperactivity disorder (ADHD) and exe...

Background: This study assessed the relationship between working memory capacity and auditory stream segregation by using the concurrent minimum audible angle in children with a diagnosed auditory processing disorder (APD).Methods: The participants in this cross-sectional, comparative study were 20 typically developing children and 15 children with a diagnosed APD (age, 9–11 years) according to...

Traditionally, virtual reality (VR) exposure-based treatment concentrates primarily on the presentation of a high-fidelity visual experience. However, adequately combining the visual and the auditory experience provides a powerful tool to enhance sensory processing and modulate attention. We present the design and usability testing of an auditory-visual interactive environment for investigating...

Speech recognition occurs when attending to speech stimuli in auditory, visual, or audiovisual modalities under optimum (e.g., in silence) or degraded listening conditions (i.e., in background noise or in individuals with hearing impairment). The present thesis contains details of the first study to show how background noise (steady-state white noise) delayed the identification of different typ...

Prominent deficits in spatial attention evident in patients with hemispatial neglect are often accompanied by equally prominent deficits in non-spatial attention (e.g., poor sustained and selective attention, pronounced vigilance decrement). A number of studies now show that deficits in non-spatial attention influence spatial attention. Treatment strategies focused on improving vigilance or sus...