Aims: The present research is focused on screening in vivo and insilico anti- amnesic activity of the ethanolic extract seeds Chenopodium quinoa. To establish exact mechanism action, phytochemical constituents were subjected to silico studies using schrodinger pass software.
 Methodology: powdered material quinoa dried extracted with ethanol by soxhlation technique. In evaluation was carri...

Female OF1 mice aged 17-18 months were compared with female OF1 mice aged 7-11 weeks for locomotor activity, pain sensitivity, and cognitive performance using the Morris water maze, passive and active avoidance, and the elevated plus-maze learning protocol. Performance of old mice was impaired compared to those of young mice for both locomotor activity, pain sensitivity, and the four cognitive ...

α-galycoceramide (α-galcer) or the common name of krn7000 is an α-gelasphin derivative. the α-galcer structure consists of a galactose combined with a ceramide in an α-configuration. social isolation (si) has been linked with enhanced inflammation, through modifications in transcriptional pathways linked with glucocorticoid, to stress. our hypothesis is to investigate mediatory role of glucocor...

Recurrent hypoglycemia (RH) is a common and debilitating side effect of therapy in patients with both type 1 and, increasingly, type 2 diabetes. Previous studies in rats have shown marked effects of RH on subsequent hippocampal behavioral, metabolic, and synaptic processes. In addition to impaired memory, patients experiencing RH report alterations in cognitive processes that include mood and a...

Background and Objective: Physical activity has long been associated with mental health. Nepeta menthoides is a native Iranian herb recently acknowledged for its anti-depressant properties. This study attempted to determine and compare the effects of swimming exercise and Nepeta menthoides on reserpine-induced depression in rats.Materials and Methods: Male rats (n=80) were assigned to 8 g...

introduction: effective perception of fear signals is crucial for organism survival. when threated, the organism indicates defensive behaviors. methods: elevated plus–maze has high efficiency for measurement of fear behavior and is widly used for fear behavior determination. increase in two parameters percent of openarm entries (%oae) and percent of time spent in the open-arm (%oat) in the elev...

Benzodiazepines (BZDs) are widely used in clinical practice as anxiolytics, hypnotics, anticonvulsants, and muscle relaxants. However, they have some undesired effects including memory problems. In continuing our research on novel benzodiazepine ligands, we are looking for ligands with less adverse effects. Previously, 4 novel derivatives of 2-phenoxy phenyl-1,3,4-oxadiazole were synthesized as...

Portulaca oleracea (PO) overgrows in the different parts of Iran. In previous studies, ethanolic extracts of PO showed antinociceptive activity, sedative in animal. This study was designed to evaluate anxiolytic effects in different doses of the aqueous decoction extracts of PO. In this study, fourty male mice (25-30 g) were used in elevated plus maze model. Different doses of the extract. (25,...

There is growing interest in flavonoids for their wide array of biological actions. In neurodegenerative disorders these naturally occurring polyphenolic compounds, are known to inhibit proinflammatory mediators such as in TNF–? and IL-6 in lipopolysaccharide (LPS) stimulated neuronal degeneration, which are associated with Alzheimer’s and Parkinson’s disease. Recent studies on flavonoids have ...