in this report, β-tubulin gene polymorphism was investigated in haemonchus contortus  populations isolated from sheep flocks in different regions of khouzestan province, southwestern iran. the samples were chosen on the basis of regional variation in benzimidazole treatment background of sheep flocks. our objective was to study the relationship between treatment background andβ -tubulin gene po...

OBJECTIVE The effect of rs4331426 polymorphism in the Chr18q11.2 locus on pulmonary tuberculosis (PTB) risk was evaluated. METHODS This case-control study included 208 PTB patients and 204 healthy subjects. Genotyping of the rs4331426 variant was conducted using polymerase chain reaction restriction fragment length polymorphism. RESULTS The frequencies of genotypes AA, AG, and GG polymorphi...

Blood samples were collected from the jugular vein of 101 clinically healthy Iranian fat-tailed sheep according to their age (5 years) and sex. Serum haptoglobin (Hp) was measured based upon the preservation of the peroxidase activity of haemoglobin, which is directly proportional to the amount of Hp. The reference value for serum Hp of apparently healthy Iranian fat-tailed sheep was 0.05-0.18 ...

background tuberculosis (tb) is one of the earliest human diseases which still is considered a public health problem. both genetic and environmental factors may contribute the susceptibility to tuberculosis. objectives akt is a serine/threonine kinase that has an important role in several cellular processes such as cell cycle control, cell survival, and cellular immigration. the akt signaling p...

genotypes of iranian zel sheep for calpastatin(cast) locus were determined by polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) and polymerase chain reaction-single strand conformation polymorphism (pcr-sscp) methods and for calpain(capn) locus by pcr-sscp. blood samples were collected from 200 purebred zel sheep of zel breeding station located in golestan province i...

Background: Despite recent decrease in the incidence of gastric cancer, it is still a common type of cancer in the north of Iran. Many evaluations have shown that polymorphisms of cytokine genes like that for interleukin 6 (IL-6), which play important roles in regulation of the immune response, can increase the risk of gastric cancer. This study examined the role of the IL-6-174 gene polymorphi...

Single nucleotide polymorphisms (SNPs) in the let-7 miRNA binding site within the 3’ untranslated region (3’UTR) of KRAS appear related to the risk of cancer. The present case-control study was conducted with 244 BC patients and 204 healthy women to examine whether KRAS polymorphisms (rs61764370 T/G and rs712 G/T) are associated with breast cancer (BC) risk in an Iranian population. The polymer...