purpose : to investigate the validity of pentacam derived parameters like corneal volume distribution and percentage increase in volume in differentiation of mild to moderate keratoconus from normal corneas methods : forty eyes with mild to moderate keratoconus and 200 normal eyes were studied by pentacam. corneal volume was calculated within diameters from 1.0 to 7.0 mm with 0.5 mm steps cente...

Abstract Patatin-like phospholipase domain-containing protein 3 (PNPLA3) is a key lipase involved in fatty liver syndrome onset and recovery humans bovine. Regulation of PNPLA3 mediated by carbohydrate response element binding (ChREBP) rodents sterol regulatory element-binding 1c (SREBP1c) humans. The objectives our study were to optimize an siRNA knockdown ChREBP SREBP1c determine if either tr...

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abstract background: the current practice to measure rv is either by bpg or helium dilution methods which may not be available in all clinics due to their cost. methods: this paper outlines a method for both direct and indirect calculation of rv via pft with acceptable sensitivity (81 %, 60% ), specificity (71 %, 94%) and validity (76%, 78%) for obstructive and restrictive lung disease respecti...

Applied Literature, however, does not have literature at its centre. Literature in this domain is a tool to solve problems and achieve goals. Using literature to teach and learn languages, the application of literature to language education, is a very handy example. Health Humanities (by Crawford, et al. and reviewed by A. Ramazani in our Journal's previous issue) comprises chapters on how lite...

A new vocabulary item has been added to English dictionaries: Covid-19. For linguists, the addition of a meaningful linguistic element to any language should change the whole language as, for T. S. Eliot, a new poem changes the whole literature of a nation. But let us see how seriously the addition of the vocabulary item Covid-19 might change the English language. According to Cambridge online ...

The emergence and distribution of drug resistance in malaria are serious public health concerns in tropical and subtropical regions of the world. However, the molecular mechanism of drug resistance remains unclear. In the present study, we performed a high-throughput RNA-Seq to identify and characterize the differentially expressed genes between the chloroquine (CQ) sensitive (3D7) and resistan...

In this study, we aimed to optimize the isolation procedure of circulating RNA from large volumes of plasma. Simultaneously, the stability and integrity of RNA from plasma samples were examined. To investigate the isolation of circulating RNA, reverse transcription-PCR analysis in combination with capillary electrophoresis was used. The presence of amplifiable RNA in plasma from healthy volunte...