A key issue in the design of a cellular manufacturing system is the formation of the machines and parts into groups or production cells. The production cells are designed to minimize the costs of inter-cell part movements and intra-cell processing, while balancing the workload within each cell. Most of the prior research represents the cell formation problem as a binary machine-part incidence m...

Selection of mammalian high-producer cell lines remains a major challenge for the biopharmaceutical manufacturing industry. Ribosomal RNA (rRNA) genes encode the major component of the ribosome but many rRNA gene copies are not transcribed due to epigenetic silencing by the nucleolar remodelling complex (NoRC) [6], which may limit the cell's full production capacity. Here we show that the knock...

The present article attempts to investigate the validity of the Comanor–Wilson Minimum Efficient Size (MES) measure. The basic assumption is that firms that have exhausted scale economies are in non-increasing returns to scale. The same firms are also assumed to have a size greater than MES estimated on sales (total turnover), employment or fixed assets. Data Envelopment Analysis (DEA) is used,...

Nowadays, manufacturers are faced with severe challenges to response rapidly to changing demands and meet various customers’ needs with respect to production volume and product profile. Reconfigurable manufacturing paradigm was proposed as an advanced manufacturing philosophy to enhance the adaptability and flexibility of manufacturing systems. By physical and logical reconfiguration, Reconfigu...

-This paper discusses and reviews a fundamental issue in cellular manufacturing--cell formation. This problem is of strategic and operational importance in that it affects the fundamental structure and the overall layout of a cellular manufacturing system. We first provide a comprehensive mathematical formulation of the cell formation problem and then propose a methodology-based classification ...

Nowadays, flexible manufacturing systems play an effective role in a variety of production and timely response to the needs of their customers. Flexible manufacturing cell is a part of this system that includes machines with flexibility in manufacturing different parts. For many years, minimizing the number of tool switches in the machines has been studied by the researchers. Most research in t...

Cellular manufacturing system is the formation of optimised machine cells, which forms part families with similar processing requirements and associates machines into machine cells in order to optimise the overall production process. To effectively solve this problem a hybrid novel approach is demonstrated in this paper, which is based on weighted average linkage clustering algorithm and fuzzy-...

The after–sales activities are nowadays acknowledged as a relevant source of revenue, profit and competitive advantage in most manufacturing industries. Top and middle management, therefore, should focus on the definition of a structured business performance measurement system for the after-sales business. The paper aims at filling this gap, and presents an integrated methodology for the after-...

In the design of a cellular manufacturing system (CMS), one of the important problems is the cell formation in the form of machine grouping and parts family. This paper investigates an allocation of parts to common and specific cells; in such a way that each common cell is able to process all required parts. Further, this paper presents a mathematical programming model comprising such constrain...