BACKGROUND Strategies employed by parasites to establish infections are poorly understood. The host-parasite interface is maintained through a molecular dialog that, among other roles, protects parasites from host immune responses. Parasite excretory/secretory products (ESP) play major roles in this process. Understanding the biology of protein secretion by parasites and their associated functi...

Investigators have pondered whether or not ESP size has an impact on mercury capture by sorbent injection or deposition on fly ash. If important, ESP size would then have an impact on how effectively a power plant captures mercury and can comply with mercury control requirements. There are two possible elements to the impact of ESP size. First, does a larger ESP enable more mercury capture to o...

A comprehensive understanding of cancer is predicated upon knowledge of the structure of malignant genomes underlying its many variant forms and the molecular mechanisms giving rise to them. It is well established that solid tumor genomes accumulate a large number of genome rearrangements during tumorigenesis. End Sequence Profiling (ESP) maps and clones genome breakpoints associated with all t...

Real-time event stream processing (RT-ESP) applications must synchronize continuous data streams despite fluctuations in resource availability. Satisfying these needs of RT-ESP applications requires predictable QoS from the underlying publish/subscribe (pub/sub) middleware. If a transport protocol is not capable of meeting the QoS requirements within a dynamic environment, the middleware must b...

Enterococci have emerged as important nosocomial pathogens with resistance to multiple antibiotics. Adhesion to abiotic materials and biofilm formation on medical devices are considered important virulence properties. A single clonal lineage of Enterococcus faecium, complex 17 (CC17), appears to be a successful nosocomial pathogen, and most CC17 isolates harbor the enterococcal surface protein ...

Web 2.0 technology enables people worldwide to collaborate over the Internet, a phenomenon known as social collaboration. While the incentives for social collaboration are primarily enthusiasm for a particular subject, building a reputation, or gaining a benefit by doing something in exchange for using services or downloading files, the emergence of human computation games has shown that the pr...

ESP-102, an extract from Angelica gigas, Saururus chinensis, and Schisandra chinensis, has been used as herbal medicine and dietary supplement in Korea. Despite the numerous bioactivities in vitro and in vivo studies, its effects on neuronal networks remain elusive. To address the neuronal effect, we examined synaptic plasticity in organotypic hippocampal slice culture with multielectrode array...

Although cancer progression is often associated with genome rearrangements, little is known about the detailed genomic architecture of tumor genomes. The attempt to reconstruct the genomic organization of a tumor genome recently resulted in the development of the End Sequence Profiling (ESP) technique, and the application of this technique to human MCF7 tumor cells. We formulate the ESP Genome ...