نتایج جستجو برای: mice model
تعداد نتایج: 2422472 فیلتر نتایج به سال:
Background and purpose: Using allogeneic and xenogeneic mesenchymal stem cells (MSCs) has had some successful results in the treatment of experimental autoimmune encephalomyelitis (EAE). But the use of its syngeneic counterparts in treatment of EAE, especially established EAE, has had some paradoxical results. This study aimed to evaluate the therapeutic potential of syngeneic bone marrow-deriv...
background & aim: cutaneous infection caused by protozoa the genus leishmania are a major worldwide health problem, with high endemicity in developing countries including middle east, africa and latin america. in the absence of a vaccine, there is an urgent need for effective drugs to replace and supplement those in current use. experimental: in this study, the in vivo efficacy of artemisia...
Background & Aim: Multiple sclerosis(MS) is a chronic autoimmune disease of unknown etiology affecting the central nervous system. The prevalence of MS is the highest where environmental supply of vitamin D is low. Some studies have shown a strong protective effect of vitamin D3 on experimental autoimmune encephalomyelitis(EAE) of MS model, but it is not known how it affects EAE. Vitamin D3...
Objective(s): Metformin (Met), an antidiabetic biguanide, reduces hyperglycemia via improving glucose utilization and reducing the gluconeogenesis. Met has been shown to exert neuroprotective, antioxidant and anti-inflammatory properties. The present study investigated the possible effect of Met on the D-galactose (D-gal)-induced aging in mice. Materials and Methods: Met (1 and 10 mg/kg/p.o.), ...
Objective(s):Sub-health has been described as a chronic condition of unexplained deteriorated physiological function, which falls between health and illness. In the present study, we evaluated the effects of Lycium barbarum polysaccharide (LBP), a polysaccharide fraction purified from Lycium barbarum (L. barbarum) on the sub-health mice. Materials and Methods:The sub-health model mice were buil...
بررسی اثر داروی آتورواستاتین بر افسردگی توسط مدل شنای اجباری در موش کوچک آزمایشگاهی نر گنادکتومی شده
Introduction: Depression is one of the most common mental disorders, which its effective treatment maintains an acceptable level of performance in patients. Concerning the different effects of sexual glands on various physiological phenomena such as depression, the purpose of this study was investigation of the effect of Atorvastatin on depression by forced swimming stress model in gonadectomiz...
background outer membrane protein d (pd) is a highly conserved and stable protein in the outer membrane of both encapsulated (typeable) and non-capsulated (non-typeable) strains of haemophilus influenzae. as an immunogen, pd is a potential candidate vaccine against non-typeable h. influenzae (nthi) strains. objectives the aim of this study was to determine the cytokine pattern and the opsonic a...
background: toxoplasma gondii is an obligate intracellular parasite that infects all mammalian cells. several antigens such as excreted/secreted antigens have been identified as a potential vaccine candidate. objective: to determine how excreted/secreted antigens from peritoneal exudates of infected mice (mesa) stimulate cell-mediated immune responses and induce protective immunity against toxo...
introduction: epidermal growth factor receptor (egfr) has been shown to play a critical role in tumor cell growth and its overexpression has been observed in many epithelial tumors. in the field of cancer vaccine research, displaying the peptide mimotope on the surface of phage particles has shown promising results. methods: in this study using m13-pviii phage display system, two constructs wer...
background preventing the seasonal or pandemic outbreak of influenza can be powerful and cost-effective. objectives in this study, we constructed a novel virus-like particle (vlp) platform that contains two hemagglutinin (ha) subtypes and evaluated immunogenicity of constructed vlp in mice. materials and methods this recombinant candidate vaccine model resulted in the expression of two has of h...
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