The activity-dependent modulation of GABA-A receptor (GABA(A)R) clustering at synapses controls inhibitory synaptic transmission. Several lines of evidence suggest that gephyrin, an inhibitory synaptic scaffold protein, is a critical factor in the regulation of GABA(A)R clustering during inhibitory synaptic plasticity induced by neuronal excitation. In this study, we tested this hypothesis by s...

Interprocessor communication (PC) overheads have emerged as the major performance limitation in parallel processing systems, due to the transmission delays, synchronization overheads, and conflicts for shared communication resources created by data exchange. Accounting for these overheads is essential for attaining efficient hardware utilization. This thesis introduces two new compile-time heur...

Declustering is a well known strategy to achieve maximum I/O parallelism in multidisk systems. Many declustering methods have been proposed for symmetrical disk systems, i.e, multi-disk systems in which all disks have the same speed and capacity. This work deals with the problem of adapting such declustering methods to work in heterogeneous environments. In such environments there are many type...

Efficient storage and retrieval of trajectory indexes has become an essential requirement for moving objects databases. The existing 3DR-tree is known to be an effective trajectory index structure for processing trajectory and time slice queries. Efficient processing of trajectory queries requires parallel processing based on indexes and parallel access methods for the trajectory index. Several...

Declustering is a technique to distribute data sets over multiple disks so that future retrievals can be well balanced over the disks and be performed in parallel. Although disk heterogeneity often exists in systems like clusters, most work on declustering has focused only on homogeneous environments. In this work, we investigate the declustering problem for a heterogeneous disk environment usi...

During the spatial estimation of geoscience resource variables, quantity or quality minerals and hydrocarbons can be represented by a broad range properties, including geochemical, geotechnical, other physical measures. Preferential sampling within region interest causes biased global parameters due to clustered patterns. Unbiased sample distribution is essential for conducting conditional simu...