نتایج جستجو برای: non genotyped
تعداد نتایج: 1328148 فیلتر نتایج به سال:
background: the piwi-interacting rna (pirna) pathway has an essential role in transposon silencing, meiosis progression, spermatogenesis, and germline maintenance. hiwi genes are critical for pirna biogenesis and function. therefore, polymorphisms in hiwi genes contribute to spermatogenesis defects and can be considered as risk factors for male infertility. the aim of the present study was to i...
Introduction Neutrophils have been involved in sepsis-induced organ damage. Neutrophils could be directly activated by TLR binding ligands including LPS. IRAK-1 is one of many intracellular proteins that are activated upon stimulation of TL receptors. This triggers a series of events that results in the migration of NF-κB into the nucleus and the activation NF-κB-dependent genes. Objectives To ...
Background: Individuals respond to statins differently due to genetic variations. One of the most significant enzymes involved in drug metabolism is CYP2D6 enzyme, coded by the CYP2D6 gene. Individuals who carry two non-functional alleles in this gene are considered as poor metabolizers (PMs). Recognizing poor metabolizers might help in preventing adverse effects of drugs. Objective: In this ...
Background NMDA receptor (NMDAR) malfunctioning has been claimed as a crucial event in Alzheimer’s disease (AD), the most common form of dementia. While synaptic NMDAR activation leads to plasticity, extrasynaptic excitotoxicity, mitotoxicity and cell death. In late onset AD, APOE4 allele is main genetic risk factor. Our aim study influence apoE4 on function. Method We isolated membranes from A...
یک دسته خاص از کدهای تصحیح خطای کوانتومی، کدهای کانولوشنال می باشند که بر حسب نحوه طراحی به دو دسته کدهای css (calderbank-shor-steane) و non-css تقسیم می شوند. علیرغم اهمیت فراوان کدهای کانولوشنال در تصحیح خطا، فقدان یک مدار کدگذار با قابلیت تحقق پذیری عملی، مانعی جدی در بهره گیری از این کدها می باشد. سه پارامتر در طراحی مدارهای کدگذار کانولوشنال اهمیت دارد؛ میزان حافظه، تعداد سطوح و غیرمخرب بو...
In genome-enabled prediction, parametric, semi-parametric, and non-parametric regression models have been used. This study assessed the predictive ability of linear and non-linear models using dense molecular markers. The linear models were linear on marker effects and included the Bayesian LASSO, Bayesian ridge regression, Bayes A, and Bayes B. The non-linear models (this refers to non-lineari...
Background: The PIWI-interacting RNA (piRNA) pathway has an essential role in transposon silencing, meiosis progression, spermatogenesis, and germline maintenance. HIWI genes are critical for piRNA biogenesis and function. Therefore, polymorphisms in HIWI genes contribute to spermatogenesis defects and can be considered as risk factors for male infertility. The aim of the present study was to i...
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