EGFR is a potential therapeutic target for treating bladder cancer, but has not been approved for clinical use yet. Metformin is a widely used antidiabetic drug and has demonstrated interesting anticancer effects on various cancer models, alone or in combination with chemotherapeutic drugs. The efficacy of gefitinib, a well-known EGFR tyrosine kinase inhibitor, combined with metformin was asses...

Glucocorticoids (GCs) are used in the treatment of cancer to induce programmed cell death in the transformed cells of the hematopoietic system and to reduce side effects. Additionally, GCs are described as an inhibitor of certain chemotherapy or radiation‑induced apoptosis and also an inhibitor of cancer progression by downregulating or upregulating the expression of several genes. The present ...

tribulus terrestris (tt) is a member of the zygophyllaceae family. traditional chinese medicine recommends the use of tt for treatment of a variety of diseases. in the present study we further investigated anti-proliferative and cytotoxic effects of tt extract on normal and several malignant cell lines. for this purpose, ttwas collected and after authentication, aqueous extract was prepared. cy...

introduction : laser therapy prevents complications of proliferative diabetic retinopathy (pdr), central retinal vein occlusion (crvo) and branch retinal vein occlusion (brvr), but its effect on visual acuity is controversial. this study evaluated the effect of laser on visual acuity in these patients. materials and methods: this interventional study conducted before–after treatment and evaluat...

Since pancreatobiliary diversion probably stimulates pancreatic growth by increasing cholecystokinin secretion, the effect of the cholecystokinin antagonist CR-1409 on this adaptive response was tested. Male Wistar rats (n = 108) weighing 220-250g were randomised to receive either pancreatobiliary diversion (n = 60) or sham diversion (n = 48) and thereafter to receive either saline injections o...

In the current work, a new set of carbohydrazide linked benzofuran-isatin conjugates (5a–e and 7a–i) was designed synthesised. The anticancer activity for compounds (5b–d, 7a, 7b, 7d 7g) measured against NCI-55 human cancer cell lines. Compound 5d most efficient, thus subjected to five-dose screen where it showed excellent broad almost all tested subpanels. Furthermore, good anti-proliferative ...