AD101 and SCH-C are two chemically related small molecules that inhibit the entry of human immunodeficiency virus type 1 (HIV-1) via human CCR5. AD101 also inhibits HIV-1 entry via rhesus macaque CCR5, but SCH-C does not. Among the eight residues that differ between the human and macaque versions of the coreceptor, only one, methionine-198, accounts for the insensitivity of macaque CCR5 to inhi...

In 1994, Ericsson Mobile Communications launched an initiative to study low-power, low-cost radio interfaces between mobile phones and their accessories. A radio-access solution was sought because it would eliminate the need for cables and overcome lineof-sight restrictions. It was also recognized that a low-cost solution would usher in wireless connectivity for a multitude of new applications ...

Somatization disorder is characterized by the presence of multiple chronic distressing somatic symptoms that are not medically explained. Patients with this condition tend to be highly anxious about their symptoms, even in the face of evidence that their condition is not medically serious. In the draft of the upcoming Diagnostic and Statistical Manual of Mental Disorders (DSM-V), this condition...

This study sought to analyze the outcome of patients with post-treatment locally recurrent uterine carcinoma treated with Au-198 seed permanent interstitial re-irradiation (Au-198 IRI). A retrospective review of the data of 15 patients with post-treatment locally recurrent uterine carcinoma treated with Au-198 IRI between 1991 and 2009 was performed to evaluate the disease response, local contr...

Anthracycline antibiotics like doxorubicin (DOX) are known to exert their antitumor effects primarily via DNA intercalation and topoisomerase II inhibition. By contrast, the noncross-resistant cytoplasmically localizing DOX analogue, N-benzyladriamycin-14valerate (AD 198), only weakly binds DNA and does not inhibit topoisomerase II, yet it displays superior antitumor activity, strongly suggesti...