The Lexical Substitution task involves selecting and ranking lexical paraphrases for a target word in a given sentential context. We present PIC, a simple measure for estimating the appropriateness of substitutes in a given context. PIC outperforms another simple, comparable model proposed in recent work, especially when selecting substitutes from the entire vocabulary. Analysis shows that PIC ...

The UCLA Parallel PIC Framework (UPIC) has been developed to provide trusted components for the rapid construction of new, parallel Particle-in-Cell (PIC) codes. The Framework uses object-based ideas in Fortran95, and is designed to provide support for various kinds of PIC codes on various kinds of hardware. The focus is on student programmers. The Framework supports multiple numerical methods,...

Neonates are highly susceptible to infectious diseases and, in general, respond poorly to conventional vaccines due to immaturity of the immune system. In the present study, we hypothesized that the anti-tetanus toxoid (TT) vaccine response of neonatal mice could be enhanced by retinoic acid (RA), a bioactive retinoid, and polyriboinosinic:polyribocytidylic acid (PIC), an inducer of IFN. Early-...

OBJECTIVE To develop a convenient screening method that can predict perioperative venous thromboembolism (VTE) and identify patients at risk of fatal perioperative pulmonary embolism (PE). METHODS Patients hospitalized for gynecological abdominal surgery (n = 183) underwent hematology tests and multidetector computed tomography (MDCT) to detect VTE. All statistical analyses were carried out u...

Indoleamine 2,3-dioxygenase (IDO) is the first and rate-limiting enzyme in the kynurenine pathway of tryptophan catabolism and has been implicated in neurotoxicity and suppression of the antiviral T-cell response in HIV encephalitis (HIVE). Here we show that the Toll-like receptor 3 (TLR3) ligand poly(I:C) (PIC) induces the expression of IDO in human astrocytes. PIC was less potent than gamma i...

BACKGROUND/AIMS Our group reported that cinnamaldehyde derivative, (E)-4-((2-(3-oxopop-1-enyl)phenoxy)methyl)pyridinium malonic acid (CB-PIC) induced apoptosis in hypoxic SW620 colorectal cancer cells via activation of AMP-activated protein kinase (AMPK) and extracellular signal regulated kinase (ERK). Herein, sensitizing effect of CB-PIC was investigated in resistant cancer cells such as pacli...