برخی از گونه ‏های زنبور تریکوگراما، دارای نوعی همزیستی با باکتری Wolbachia هستندکه باعث القاء بکرماده ‏زایی در آنها می‏شود. جمعیت‌هایی این پارازیتوئید تخم آفات که نتاج ماده بیشتری تولید می‌کنند، می‌توانند بالقوه توان بالاتری برخوردار باشند. پس شناسایی یک جمعیت بومی آلوده به ولباکیا Trichogramma brassicae، بررسی‏ هایی منظور ارزیابی توانایی‌های تک‏جنسی (A) قیاس جمعیت‌‏های دوجنسی طبیعی (B) و تغذیه...

Top1 inhibition by camptothecin (CPT) perturbs RNA polymerase II (Pol II) density at promoters and along transcribed genes suggesting an involvement of Top1 in Pol II pausing. Here, we demonstrate that Top1 inhibition favors Pol II escape from a promoter-proximal pausing site of the human HIF-1a gene in living cells. Interestingly, alternative splicing at exon 11 was markedly altered in nascent...

The switch to the angiogenic phenotype represents a critical checkpoint during tumor progression. The acquisition of new capillary vessels provides newly vascularized tumor nodules with a distinct biological advantage over their avascular counterparts by conferring upon them the ability to expand and develop both locally and metastatically. To identify the molecules and mechanisms underlying th...

Rampant activity of the hypoxia-inducible factor (HIF)-1 in cancer is frequently associated with the malignant progression into a harder-to-treat, increasingly aggressive phenotype. Clearly, anti-HIF strategies in cancer cells are of considerable clinical interest. One way to fine-tune, or inhibit, HIF's transcriptional outflow independently of hydroxylase activities could be through competing ...

Introduction to HIF Pathway T he evolutionarily conserved hypoxia-inducible factor (HIF) pathway is present ubiquitously in mammalian cells and plays a critical role in the regulation of energy metabolism, especially glucose utilization. HIF is a transcription factor consisting of an O2-sensitive HIF-a (HIF-1a or HIF-2a) and the O2-insensitive HIF-1b subunit. 2 Under most physiologically normox...

Obesity is associated with tissue hypoxia and the up-regulation of hypoxia inducible factor 1 alpha (HIF-1α). Prior studies in transgenic mice have shown that HIF-1α plays a role in the metabolic dysfunction associated with obesity. Therefore, we hypothesized that, after the development of diet-induced obesity (DIO), metabolic function could be improved by administration of HIF-1α antisense oli...

MicroRNAs (miRNAs) have recently been reported play a crucial role in some tumors. In order to investigate the association of miR-195 with hemangioma, we investigate the expression of miR-195 in hemangioma tissues and its role in biological behavior of XTPS-1 and HemEChemangioma cancer cell lines. Quantitative qPCR results showed miR-195 was significantly down-regulated in hemangioma tissues co...