Background and Objective: The drug resistance mutations are key elements in the failure of long-term treatment of Hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infections. The mutation in the YMDD motif in the P gene of HBV is the most critical factor in antiviral drug (especially lamivudine) resistance. This study aimed to assess the YMDD motif and other polymerase gene mutati...

Background & Aims: Pseudomonas aeruginosa is a gram-negative opportunistic pathogen and one of the mortality causes of nosocomial infections. One of the drug resistance mechanisms in P.aeruginosa is mutation in negative regulator genes of mexAB-oprM efflux pump system such as nalD. The aim of this study was to investigate the role of nalD mutations in P. aeruginosa isolates of Guilan province i...

Background: Appearance of multi-drug resistance (MDR) Acinetobacter baumannii imposes limitation on antibiotic therapy in patients. Detection of MDR A. baumannii can play a crucial role to prevent MDR strains spreading in hospitals. The aim of this study was determination the efflux pumps gene expression in tigecyclin resistance strains in collected isolates from selected training hospitals in ...

salmonella is one of the most important zoonotic pathogens with many virulence factors playing a major role in its pathogenesis. the aims of this study were to detect spva, int2 and invc virulence genes of different salmonella serotypes isolated from various clinical animal and human sources, and to investigate antibiotic resistance patterns among these serotypes. using a pcr assay, a total of ...

abiotic stress such as cold and drought has adverse effects on plants growth and development. abiotic stress resistance is one of the most important goals in plant breeding. this goal can be achieved through transcription factor gene transfer to plants. recent studies show many successes in improving abiotic stress resistance by use of transcription factor gene transfer. the objective of the re...

Background. Irisin is the result of the proteolysis of fibronectin type III domain-containing protein 5, the levels of which are determined by physical activity. Objective(s). This study aims to identify changes in FNDC5 gene expression and the heart muscle irisin levels in male rats following 8 weeks resistance and endurance training. Methods. Fifteen male rats (10-12 weeks old and 331.8&plu...

Salmonella is one of the most important zoonotic pathogens with many virulence factors playing a major role in its pathogenesis. The aims of this study were to detect spvA, int2 and invC virulence genes of different Salmonella serotypes isolated from various clinical animal and human sources, and to investigate antibiotic resistance patterns among these serotypes. Using a PCR assay, a total of ...