background: endometriosis is a chronic and progressive gynecological disorder and is manifest by dysmenorrhea and a major cause of infertility and chronic pelvic pain. the study was designed to compare the value of cervico-vaginal fluid of interleukin-1? (il-1?) in patients with and without endometriosis. materials and methods: fifty women were assessed in this case control study. the case grou...

it seems that endometriosis plays an important role in female factor infertility but a clear causal relationship has yet to be established. this case-control study was conducted to determine and compare the frequency and severity of endometriosis in 100 infertile women and 120 fertile multi-para women as control group. descriptive statistics, student t test and chi square test were used in anal...

Abstract Study question Do immune cells regulate progesterone resistance and endometrial receptivity of eutopic stromal (ESCs) by transforming growth factor-β1 (TGF-β1)? Summary answer By activating TGF-β/Smad signaling in ESCs, elevated TGF-β1 from CD45+ could attenuate expression receptor (PR), further decrease receptivity. What is known already Endometriosis a hormone-dependent disease relat...

Background: Macrophage migration inhibitory factor (MIF) is a key pro-inflammatory cytokine that is secreted by accumulated active macrophages in ectopic tissue of endometriosis. MIF is involved in pathophysiological events of endometriosis, such as angiogenesis and cell proliferation. MIF that stimulates the synthesis of PGE2, leads to over-expression of local estradiol synthesis in endometrio...