Background & Aims: Hepatitis C virus (HCV) infection is a leading cause of chronic liver disease worldwide. The clearance of the HCV is dependent on cytokines control led by genetic. The purpose of this study was to investigate the impact of Lymphotoxin (LT-A) polymorphism at +252 in susceptibility to chronic hepatitis C. Methods: In this case-control study, 120 individuals infected by HCV and ...

background: cytokines and specially interferon-gamma (ifn-g) are largely responsible for the regulation of the protective im­mune response against mycobacterial infections. several studies have clarified the importance of common variants of ifn- g gene regarding the susceptibility to tuberculosis. bacille calmette-guérin (bcg) vaccine that is used to prevent se­vere forms of tuberculosis could ...

Background and aim: Exonuclease1 (EXO1) is a member of the RAD2 nuclease family which is involved in mismatch repair (MMR) system and contributes to the maintenance of genomic stability, modulation of DNA recombination and cell cycle arrest mediation. K589E (rs1047840) as a potentially functional polymorphism in EXO1 gene may alter cancer risk by influencing its repair activity. Method: We desi...

Abstract. As an excellent local sheep breed in China, Hu have the characteristics of producing more lambs and good motherhood. The purpose this study was to identify polymorphism mitogen-activated protein kinase 5 (MAP3K5) gene determine whether it associated with body size traits (body height, length, chest circumference, cannon circumference) sheep. MAP3K5 identified by using PCR amplificatio...

Aim The aim of this study is to demonstrate the role of CCND1 gene polymorphism, A870G, in susceptibility to sporadic colorectal cancer in Iranian population. Background It has been distinguished that CCND1 gene is one of the main genes in Wnt signaling pathway which involves in generating colorectal cancer. Nonetheless, there is no consistent result in terms of association between the geneti...

the families of tgf-β proteins are the most important growth factors in the ovary for growth and differentiation of early ovarian follicles. three related oocyte-derived members of the transforming growth factor-β superfamily namely growth differentiation factor 9 (gdf9), bmp15 and bmpr-ib have been shown to be essential for follicular growth and ovulation. different mutations in the gdf9 gene ...