نتایج جستجو برای: rat model of alzheimer

تعداد نتایج: 21390924  

Journal: :The Journal of biological chemistry 2016
Haoling Qi Sudhakaran Prabakaran François-Xavier Cantrelle Béatrice Chambraud Jeremy Gunawardena Guy Lippens Isabelle Landrieu

Tau neuronal protein has a central role in neurodegeneration and is implicated in Alzheimer disease development. Abnormal phosphorylation of Tau impairs its interaction with other proteins and is associated with its dysregulation in pathological conditions. Molecular mechanisms leading to hyperphosphorylation of Tau in pathological conditions are unknown. Here, we characterize phosphorylation o...

ژورنال: Iranian Rehabilitation Journal 2016

Objectives: This paper aims to explore whether the Persian-speaking patients of different stages, ranging from mild to moderate, have a deficit in semantic processing by comparing the performance of Alzheimer’s patients with that of the healthy individuals. Methods: The subjects of both the groups of Alzheimer’s patients and healthy control were matched for age, the state of monoli...

Introduction: Memantine (MEM) is a noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist clinically used for the treatment of Alzheimer disease (AD) in mild to severe conditions. The present study was conducted to investigate the effects of memantine on the spontaneous firing frequency of CA1 pyramidal neurons in rats caused by an electrical lesion of Nucleus Basalis Magnocellularis (...

Journal: :مجله علوم اعصاب شفای خاتم 0
ali ebrahimi a. islamic azad university, mashhad branch, mashhad, iran b. members of mashhad neuroscience research group of islamic azad university, mashhad branch, mashhad, iran anahita ghazaghi a. islamic azad university, mashhad branch, mashhad, iran b. members of mashhad neuroscience research group of islamic azad university, mashhad branch, mashhad, iran malihe bahadoran a. islamic azad university, mashhad branch, mashhad, iran b. members of mashhad neuroscience research group of islamic azad university, mashhad branch, mashhad, iran faramarz khojaste a. islamic azad university, mashhad branch, mashhad, iran b. members of mashhad neuroscience research group of islamic azad university, mashhad branch, mashhad, iran

alzheimer's disease (ad) is a chronic neurodegenerative disease that accounts for 60 to 80 percent of all dementia cases. the exact cause of alzheimer`s disease is still unknown, but recent studies suggest neuro-inflammation as an important part of the pathogenesis of the disease. this brings in mind using non-steroidal anti-inflammatory drugs (nsaid) as treatment or prevention of the dise...

پایان نامه :دانشگاه آزاد اسلامی - دانشگاه آزاد اسلامی واحد شاهرود - دانشکده پزشکی 1390

nitric oxide (no) is a small molecule synthesized by most of mammalian cells with diverse biological activities including vasodilatation, host defense and wound healing. impaired wound healing is a common occurrence among diabetics and patients receiving glucocorticoid therapy. on the other hand the application of laser in biomedical area have been increased. thus, the current studies were desi...

پایان نامه :وزارت علوم، تحقیقات و فناوری - پژوهشگاه دانشهای بنیادی (مرکز تحقیقات فیزیک نظری و - پژوهشکده علوم نانو 1392

among the low–dimensional allotropes of carbon, nanotubes and graphene have attracted very much attention from nano–science and nanotechnology specialists. they have been proposed as building blocks in nanometer device engineering. however, these structures are not defect–free. in this thesis, we focused on defective carbon nanotubes and graphene, and studied the effect of couple of very common...

Background: Recently, researchers have considered extremely low-frequency electromagnetic fields (ELF-EMFs), as one of the non-invasive therapies, in the treatment of many severe neurological disorders, including Alzheimer Disease (AD). AD is a progressive neurodegenerative disease characterized by the deposition of amyloid plaques in the brain. However, the increase in microglial cells increas...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه اصفهان - دانشکده زبانهای خارجی 1392

abstract this study investigated the predictability of variables from a motivational framework as well as individuals qualities to predict three non-linguistic outcomes of language learning. gardners socio-educational model with its measures has been used in the current study. individual qualities presented in this study include (1) age, (2) gender, and (3) language learning experience. the...

Journal: :مجله علوم اعصاب شفای خاتم 0
maryam moghadamqaeni student research committee, facuilty of medicine, islamic azad university, mashhad branch, mashhad, iran zahra sheidaemehne student research committee, facuilty of medicine, islamic azad university, mashhad branch, mashhad, iran

alzheimer disease (ad) is a neurodegenerative disorder and the most common form of dementia. increasing evidence suggests that alzheimer's disease pathogenesis is not restricted to the neuronal compartment, but includes strong interactions with immunological mechanisms in the brain. in vitro and animal studies have linked neuroinflammation to alzheimer's disease (ad) pathology. studie...

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