Several factors contribute to nuclear mRNA export in Saccharomyces cerevisiae, including Mex67p, Mtr2p, Gle1p, Nup159p, Dbp5p, and Rip1p. Strains carrying mutations in these factors show rapid and dramatic nuclear accumulation of poly(A)(+) RNA. We have characterized two heat shock mRNAs, SSA4 and HSP104, in these mutant backgrounds; each transcript concentrates in a single intranuclear focus. ...

introduction: preterm birth is a risk factor for a number of conditions that requires comprehensive examination. our study was designed to investigate the impact of preterm birth on the processing of auditory stimuli and brain structures at the brainstem level at a preschool age.   materials and methods: an auditory brainstem response (abr) test was performed with low rates of stimuli in 60 chi...

Background. Execution of fitness testing in physical education classes is influenced by students’ motivation. Therefore, addressing new testing approaches seems necessary to more accurately measure student performance. Objectives. This study presents changes in fitness performance after applying a physical fitness tests battery (without external stimuli - WS) and with external stimuli (verbal ...

speech delay with an unknown cause is a problem among children. this diagnosis is the last differential diagnosis after observing normal findings in routine hearing tests. the present study was undertaken to determine whether auditory brainstem responses to click stimuli are different between normally developing children and children suffering from delayed speech with unknown causes. in this cr...

Nucleo-cytoplasmic transport of proteins is mediated by nuclear export signals, identified in various proteins executing heterologous biological functions. However, the molecular mechanism underlying the orchestration of export is only poorly understood. Using microinjection of defined recombinant export substrates, we now demonstrate that leucine-rich nuclear export signals varied dramatically...