The aim of the present study was to evaluate the pesticide residues in human blood samples of volunteers related to Hyderabad and Mirpurkhas districts, Pakistan. The volunteers of both districts were divided into four groups on the basis of their exposure period to pesticides i.e. Group A—5 to 9 years, Group B—10 to 14 years, Group C—15 to19 years and Group D—above 20 years. Out of total 188 vo...

Five sample of each vegetable in each location per month was collected from three markets of Jorhat districts for three months. Three markets are Jorhat vegetable market, Lichubari vegetable market and Teok vegetable market of Jorhat district. The vegetable species are Tomato, Cabbage, Cauliflower, Brinjal, French bean, Cow pea and Okra. Individual species of samples were mixed and analyzed in ...

Humans are usually exposed to several pesticides simultaneously; consequently, combined actions between pesticides themselves or between pesticides and other chemicals need to be addressed in the risk assessment. Many pesticides are efficient activators of pregnane X receptor (PXR) and/or constitutive androstane receptor (CAR), two major nuclear receptors that are also activated by other substr...

Humans are usually exposed to several pesticides simultaneously; consequently, combined actions between pesticides themselves or between pesticides and other chemicals need to be addressed in the risk assessment. Many pesticides are efficient activators of pregnane X receptor (PXR) and/or constitutive androstane receptor (CAR), two major nuclear receptors that are also activated by other substr...

Over the centuries, humans have developed many ingenious methods in their attempts to control herbs, weeds, insects, invertebrates and microorganisms that constantly threatened the supply of food and fibre as well as posed a threat to public health. The aim of present study was to find out the protective nature of antioxidant property of vitamin E in against chlorpyrifos and endosulfan toxicity...

P-glycoprotein (P-gp) has been associated with a number of neurodegenerative diseases, including Parkinson's disease, although the mechanisms remain unclear. Altered transport of neurotoxic pesticides has been proposed in Parkinson's disease, but it is unknown whether these pesticides are P-gp substrates. We used three in vitro transport models, stimulation of ATPase activity, xenobiotic-induce...

Dioxin and pesticides with xenoestrogenic activity are environmental contaminants that are suspected of promoting human diseases such as cancers. However, few studies have addressed the molecular consequences of a combination of these contaminants, a situation that is likely to occur in the environment. We investigated the effects of natural and xenoestrogens on basal and 2,3,7,8-tetrachlorodib...