Hepatic lipid infiltration (steatosis) is a complication of the metabolic syndrome and can progress to nonalcoholic steatohepatitis and severe liver injury. Microsomal cytochrome P450 (P450) drug oxidases are down-regulated in experimental steatosis. In this study we evaluated the separate and combined effects of lipid accumulation and P450 down-regulation on the microsomal oxidation of the ant...

1. The metabolic responses to an oral glucose tolerance test (100 g) and an intravenous insulin provocation test (0-1 i.u./kg) were studied in nine control subjects and nine patients with Huntington's chorea. 2. Plasma glucose responses to these stimuli were identical in both groups. 3. High fasting concentrations of non-esterified fatty acid (NEFA) were recorded in the choreic patients when co...

background and objectives:wild sage(salvia macrosiphon boiss.) known as “marvak” in persian is one of the polymorphic and abundant plants of lamiaceae. the plants whole seeds usually soaked or boiled in hot water are widely used for inflammatory ailments in folk medicine. documents have shown that there is scant information on the chemical constituents of this plant seeds. the current study was...

Consistent with its central importance in lipid and energy homeostasis, lipolysis occurs in essentially all tissues and cell types, including macrophages. The hydrolytic cleavage of triacylglycerol by adipose triglyceride lipase (ATGL) generates non-esterified fatty acids, which are subsequently used as essential precursors for lipid and membrane synthesis, mediators in cell signaling processes...

Two groups of adult male rats 8 weeks old were fed a 10 p. 100 protein (casein) diet with or without 2 p. 100 methionine. After 8 rats in each group were killed at 10 a.m. on experimental days 1, 2, 4, 8 and 21, we studied the profiles of plasma non-esterified fatty acids (NEFA) and of the hepatic activities of pyruvate kinase (PK), phosphoenolpyruvate carboxykinase (PEPCK), glucose-6-phosphate...

Material and methods Multiparous cows (n=74) at the Swedish Livestock Research Centre Lövsta, with BCS from 2 to 4.25 the first week PP were enrolled. Insulin, non-esterified fatty acids (NEFA), glucose and insulin like growth factor 1 was determined week two PP. The Revised Quantitative Insulin Sensitivity Check Index (RQUICKI) was used to estimate IS. Progesterone in milk was determined twice...

Background and Objectives: Breast milk composition is affected by several factors such as maternal diet and body mass index. Milk fats include a major calorie content of the milk, which changes dramatically throughout the lactation. The aim of the present study was to assess breast milk fatty acid profile in overweight and obese mothers and its correlations with maternal body mass index. Mater...

1. In the dog and monkey bilateral nephrectomy or ureteral ligation results in a marked, progressive increase of total fatty acids, of free and esterified cholesterol, of phospholipid, and of free fat of serum. 2. No such changes follow unilateral nephrectomy, splenectomy, or fasting. 3. The increase after bilateral nephrectomy is not inhibited by glucose administration. 4. A marked increase of...