LEPTIN WAS CLONED IN 1994 and shown to be secreted from adipocytes (5). This and subsequent studies demonstrated that leptin is made and secreted in proportion to the fat content of individual adipocytes (4). Under normal physiological conditions, the concentration of circulating leptin is inversely related to body fat, or energy, content (2). It is transported past the bloodbrain barrier and a...

The present study was conducted to assess the effects of leptin on food intake and energy balance in the presence or absence of corticosterone. Three cohorts of C57BL/6 mice differing in their corticosterone status [nonadrenalectomized (intact), adrenalectomized (ADX), and ADX with corticosterone replacement] were infused with either saline or leptin at a dose of 150 μg ⋅ kg-1 ⋅ day-1. Througho...

Leptin regulates energy balance through central circuits that control food intake and energy expenditure, including proopiomelanocortin (POMC) neurons. POMC neuron-specific deletion of protein tyrosine phosphatase 1B (PTP1B) (Ptpn1(loxP/loxP) POMC-Cre), a negative regulator of CNS leptin signaling, results in resistance to diet-induced obesity and improved peripheral leptin sensitivity in mice,...

The adipose tissue-derived hormone leptin acts via its receptor (LRb) in the brain to regulate energy balance and neuroendocrine function. LRb signaling via STAT3 and a number of other pathways is required for the totality of leptin action. The failure of elevated leptin levels to suppress feeding and mediate weight loss in common forms of obesity defines a state of so-called leptin resistance....

background leptin, a protein released from adipose tissue, could have significant role in pathogenesis of obesity and type 2 diabetes mellitus. conclusions it is speculated that lower serum leptin levels in diabetic patients may be a consequence of male gender. moreover, results suggest that serum leptin level in women is influenced differently than that in men. results the serum leptin level i...

the aim of this study was to determine the effect of eight-week resistance training on muscular strength and balance in men with multiple sclerosis (ms). for this purpose, out of 40 ms patients in iran ms society, 18 patients (mean age 34.05±7.8 yrs; mean expanded disability status scale 2.94±1.54 score; mean weight 67.83±11.58 kg; and mean body mass index 22.40±3.81kg/m2) were randomly divided...