background: snakebite in iran has been a health concern. however, management of snakebite is not standardized and varies from center to center. this study is aimed at devising an evidence-based comprehensive protocol for snakebite management in iran, to reduce unnecessary variations in practice. materials and methods: a narrative search in electronic databases was performed. fifty peer-reviewed...

BACKGROUND Development of a manual or well-defined criterion for prioritizing the topics of clinical practice guidelines (CPGs) will help validate and organize this process evermore. This study was conducted to design an applicable manual that would prioritize the CPG topics for family physicians. METHODS This study was a multi-stage method using a qualitative approach that was conducted for ...

BACKGROUND Solid-organ transplant recipients have a high incidence of cutaneous squamous cell carcinoma (SCC) and often develop multiple and aggressive tumors. There are few published studies or reviews, which provide guidance to the clinician in the treatment of these patients. OBJECTIVE The objective was to develop useful clinical guidelines for the treatment of skin cancer in organ transpl...

Radiofrequency ablation (RFA) is a thermal technique widely used for the management of benign thyroid nodules. To date, five academic societies in various countries have reported clinical practice guidelines, opinion statements, or recommendations regarding use RFA. However, despite some similarities, there are also differences among and consensus required safe effective treatment Asian countri...

  Introduction: Journal clubs play an important role in teaching Evidence Based Medicine (EBM). Evidence based journal clubs focus on real problems of the group, and set a minimum level of evidence for articles to be presented, and in the end a clinical bottom line is set to be used in the daily clinical practice. In this article, we have explained our experience in r...

The primary clinical motor symptoms of Parkinson's disease (PD) result from loss of dopaminergic (DA) neurons in the substantia nigra (SN). Consequently, neurogenesis of this group of neurons in the adult brain has drawn considerable interest for the purpose of harnessing endogenous neurogenerative potential as well as devising better strategies for stem cell therapy for PD. However, the existe...

BACKGROUND: American College of Chest Physicians’ (CHEST) new Living Guidelines Model will not only provide clinicians with guidance based on the most clinically relevant and current science but will also allow expert-informed guidance to fi ll in any gaps in the existing evidence. Th ese guidance documents will be updated, as necessary, using one or more of three processes: (1) evidence-based ...

BACKGROUND Patient engagement in clinical practice guideline (CPG) development is recommended by multiple institutions and instruments measuring guideline quality. Approaches to engaging patients, however, vary between oversight organizations, quality tools and guideline developers. OBJECTIVE We propose a ten-step framework outlining steps and options for patient engagement in guideline devel...