Amyloid-β (Aβ) self-assembly into cross-β amyloidfibrils is implicated in a causative role in Alzheimer’s disease pathology.Uncertainties persist regarding the mechanisms of amyloid self assembly and the role of metastable prefibrillar aggregates. Aβ fibrilsfeature a sheet-turn-sheet motif in the constituent β-strands; as such, turn nucleation has been proposed as a rate-limiting step in the se...

Proper planning of assembly lines is one of the production managers’ concerns at the tactical level so that it would be possible to use the machine capacity, reduce operating costs and deliver customer orders on time. The lack of an efficient method in balancing assembly line can create threatening problems for manufacturing organizations. The use of assembly line balancing methods cannot balan...

self-assembly of densely packed zno nanorods were grown on porous silicon (ps) substrate by low-temperature chemical bath deposition. the structural and optical properties of the obtained zno nanostructures on ps substrate were systematically studied. the strong and sharp (002) peak compared with other peaks in the x-ray diffraction (xrd) indicated thatzno nanorods formed with superior orientat...

This study presents a reduction of production disturbances of a shoemaking industry through discrete event simulation approach. The study is conducted at Peacock Shoe factory found in Addis Ababa, Ethiopia.  This factory faces line balancing problem that becomes production disturbance for its assembly lines. Detail time study is carried out for the selected shoe model using stopwatch. Assembly ...

given the importance of transcriptome analysis in various biological studies and considering thevast amount of whole transcriptome sequencing data, it seems necessary to develop analgorithm to assemble transcriptome data. in this study we propose an algorithm fortranscriptome assembly in the absence of a reference genome. first, the contiguous sequencesare generated using de bruijn graph with d...

the strategic pricing decisions of assembly products in assembly products supply chain are studied in this paper. firstly, a two-stage assembly products supply chain model is developed. by building nash game model, the nash equilibrium solution of pricing strategy of supplier and assemblers is obtained. next, a union decision model is built to analyze the optimal combination pricing strategy of...

In this paper we are to present a practical application of Axiomatic Design (AD) methodology, as a roadmap to lean production, in redesigning a car body assembly line. Axiomatic Design theory provides a framework to simplify the whole problem. According to the AD principles, a hierarchical structure has been developed. The developed structure originated in lean manufacturing principles and exis...

Assembly lines are flow-oriented production systems that are of great importance in the industrial production of standard, high-volume products and even more recently, they have become commonplace in producing low-volume custom products. The main goal of designers of these lines is to increase the efficiency of the system and therefore, the assembly line balancing to achieve an optimal system i...

background: ergonomics is a science that provides methods of creating reasonable adaption between occupation and worker by improving usability through consideration of job demands and human ability to satisfy them. a deep understanding of user’s thoughts on and attitudes toward utilizing a tool could improve its design. in the present study, two cushions designed particularly for one of car ind...

Tolerance analysis of mechanical assemblies is an important tool in reliable design of products at low cost and good quality. Using this tool, it is possible in manufacturing stage to observe the effect of parameters on assembly requirements. The direct linearization method is a useful method which runs based on vector loop analysis. In this research, the DLM method is used to analyze the toler...