Background: Methotrexate (MTX) is an anti-metabolite drug used in the treatment of many cancers and autoimmune diseases. Methods: This study investigated the protective effect of flaxseed oil, sesame seed oil, and their mixture on the MTX-induced hepatorenal toxicity. Thirty rats divided into five groups of: normal control, MTX control, and flaxseed oil, sesame seed oil, and the mixture groups...

A novel microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor induced kidney injury at exposures representing less than 4 times the anticipated efficacious exposure in man during a 7-day toxicity study in rats. The findings consisted mainly of tubular lesions and the presence of crystalline material and increases in plasma urea and creatinine. In vitro and in vivo metabolic profiling genera...

Background: In recent years, plant materials have been widely explored as sources of insect pest control agents with little or no study on their toxicity. The present study aimed to detect the biochemical alterations in liver and kidney associated with acute oral toxicity of the extracts of B. micrantha and M. villosus in albino rats. Methods: Twenty seven albino rats, weighing between 150-1...

introduction: the impact of chromium exposure was studied on liver, kidney, testis, spleen, cerebrum and cerebellum of male wistar rats (80-100 g body weight). material & method: it was observed that treatments of rats with chromium (i.p. at a dose of 0.8 mg / 100 g body weight per day) for a period of 28 days caused significant increase in chromium content while declining the body weight along...

3,4-methylenedioxymethamphetamine (mdma) or ecstasy, has had a widely spread popularity among young adults in recent years. kidney toxicity is one of the consequences of ecstasy. the studies have shown that ecstasy is metabolized by cytochrome p450 to reactive electrophil metabolites which detoxify by glutathione (gsh) conjugation. to our knowledge in vivo study of the effect of glutathione on ...

Objective(s): Long term consumption of ethanol may induce damage to many organs. Ethanol induces its noxious effects through reactive oxygen species production, and lipid peroxidation and apoptosis induction in different tissues and cell types. Previous experiments have indicated the antioxidant characteristics of thymoquinone, the active constituent of Nigella sativa fixed oil, against biologi...

background: garcinia kola seed is consumed indiscriminately in nigeria without recourse to its potential toxicity. therefore, this study was aimed at assessing the toxicity of the aqueous extract of g. kola seeds on selected tissues of male rats.  methods: thirty male rats (215.00 ± 18.58 g) were assigned into four groups: a, b, c and d which received 0.5 ml of distilled water, 25, 50 and 100 m...