Introduction: The inflammatory response requires a coordinated integration of various signaling pathway including cyclooxygenase (COX). COX catalyzes the formation of prostaglandins from arachidonic acid. Among prostaglandins, 15-Deoxy-D12, 14-prostaglandin J2 (15d-PGJ2), an endogenous ligand of Peroxisome proliferator-activated receptor-gamma (PPAR-γ), has been demonstrated to have anti-inflam...

Little information on the effects of a high α-linolenic acid (C18:3n-3) diet fatty composition and lipid-producing gene expression in hepatopancreas from Yellow River carp (Cyprinus carpio). In study, 60 common juveniles were fed for 50 days, supplemented with linseed oil (LO), control without addition to evaluate effect lipid peroxisome proliferator-activated receptors (PPAR-α), delta-6 desatu...

Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-activated transcription factors that include PPAR-alpha, PPAR-gamma, and PPAR-delta. We hypothesized that PPAR expression in blood vessels could be reduced in hypertension to result in increased vascular growth and reduced apoptosis. We investigated the abundance of PPAR-alpha and PPAR-gamma in aorta and mesenteric arter...

Long-chain fatty acids (FA) coordinately induce the expression of a panel of genes involved in cellular FA metabolism in cardiac muscle cells, thereby promoting their own metabolism. These effects are likely to be mediated by peroxisome proliferator-activated receptors (PPARs). Whereas the significance of PPAR in FA-mediated expression has been demonstrated, the role of the PPAR / and PPAR isof...

Sanderson LM, Boekschoten MV, Desvergne B, Müller M, Kersten S. Transcriptional profiling reveals divergent roles of PPAR and PPAR / in regulation of gene expression in mouse liver. Physiol Genomics 41: 42–52, 2010. First published December 15, 2009; doi:10.1152/physiolgenomics.00127.2009.—Little is known about the role of the transcription factor peroxisome proliferator-activated receptor (PPA...

Objective—Peroxisome proliferator–activated receptor(PPAR ) is a ligand-activated transcription factor that controls lipid metabolism and inflammation. PPAR is activated by fibrates, hypolipidemic drugs used in the treatment of dyslipidemia. Previous studies assessing the influence of PPAR agonists on atherosclerosis in mice yielded conflicting results, and the implication of PPAR therein has n...

Peroxisome proliferator-activated receptors (PPARs) are a family of ligand-activated transcription factors that include PPAR-a, PPAR-g, and PPAR-d. We hypothesized that PPAR expression in blood vessels could be reduced in hypertension to result in increased vascular growth and reduced apoptosis. We investigated the abundance of PPAR-a and PPAR-g in aorta and mesenteric arteries from young (6-we...