incorporation of functional foods and nutraceuticals such as carotenoids which suffer from poor water solubility and low bioavailability into nano-sized delivery systems can improve their solubility, stability and oral bioavailability. the aim of this study was to prepare β-carotene nanodispersion and investigate the effects of preparation parameters by means of response surface methodology usi...

response surface methodology is a common tool in optimizing processes. it mainly concerns situations when there is only one response of interest. however, many designed experiments often involve simultaneous optimization of several quality characteristics. this is called a multiresponse surface optimization problem. a common approach in dealing with these problems is to apply desirability funct...

for all industrial processes, modelling, optimisation and control are the keys to enhance productivity and ensure product quality. in the current study, the optimization of process parameters for improving the conversion of isoeugenol to vanillin by psychrobacter sp. csw4 was investigated by means of taguchi approach and box-behnken statistical design under resting cell conditions. taguchi desi...

The aim of the presented approach is to combine two views on robustness within a comprehensive design approach. These two main views are on the one hand the resistance to extraordinary (unforeseen) events, and on the other hand the consideration of uncertainty in structural parameters in order to monitor and reduce the variation of structural responses. To capture this, an enhanced robustness m...

Device robust-design is inherently a multiple-objective optimization problem. Using design of experiments (DoE) combined with response surface methodology (RSM) can satisfy the great incentive to reduce the number of TCAD simulations that need to be performed. However, the errors of RSM models may large enough to diminish the validity of the results for some nonlinear problems. To find the feas...

this study concerns the scope to improve water flooding in heterogeneous reservoirs. we used an existing, in-house developed, optimization program consisting of a reservoir simulator in combination with an adjoint-based optimal control algorithm. in particular we aimed to examine the scope for optimization in a two-dimensional horizontal reservoir containing a single high permeable streak, as a...

There have been many productive methods developed so far for optimization of multiple response surface (MRS) problems. This paper tends to review the most seminal approaches in MRS and discuss the strength and weakness of each of the approaches through existing aspects in MRS. A numerical example is included to compare results by different methods. Finally some of the prominent areas for future...