OBJECTIVES The goal of this research was to clarify whether the benefit of reperfusion therapy for myocardial infarction was sustained long-term and to assess the gain in life expectancy by reperfusion therapy. BACKGROUND Reperfusion therapy in acute myocardial infarction reduces infarct size and increases hospital survival. METHODS We analyzed the 20-year outcome of 533 patients (mean age ...

BACKGROUND There is clear evidence that reperfusion therapy improves survival in selected patients with an acute myocardial infarction. However, several studies have suggested that many patients with an acute myocardial infarction do not receive this therapy. Whether this underutilization occurs in patients appropriate for such therapy remains unclear. METHODS AND RESULTS We examined the use ...

Abstract Background Trimetazidine as adjunctive therapy in cardioischemic patients has shown improvement angina and left ventricular ejection fraction. Recent trials have conflicting evidence on its effect hard clinical outcomes. Purpose The objective of this meta-analysis is to compare the efficacy trimetazidine versus placebo reducing cardiac mortality major adverse events (MACE) coronary art...

Abstract Purpose of Review In acute ST-segment elevation myocardial infarction (STEMI), successful restoration blood flow in the infarct-related coronary artery may not secure effective reperfusion. The mortality and morbidity associated with MI remain significant. Microvascular obstruction (MVO) represents failed microvascular MVO is under-recognized, independently adverse cardiac prognosis an...

Following acute myocardial infarction (AMI), early reperfusion therapy with thrombolytic therapy or primary percutaneous coronary intervention therapy (PCI) is the best way to salvage the heart by limiting the infarct size and preserving the left ventricular function. The early survival benefits of reperfusion are probably sustained lifelong and after 20 years, the survival rate of 27% in patie...

OBJECTIVES This study sought to examine the influence of time to reperfusion on myocardial salvage. BACKGROUND Major trials of reperfusion therapy for myocardial infarction (MI) have demonstrated improved outcome for patients achieving earlier reperfusion. However, some patients experience significant benefit despite delayed reperfusion. METHODS Fifty-five patients with a first anterior MI ...

Reperfusion therapy represents an important step forward in the management of patients with ST-segment elevation myocardial infarction (STEMI). Few medicinal treatments have been evaluated so well. In numerous randomized controlled trials, reperfusion therapy proved to reduce infarct size and improve early and long-term clinical outcome when compared with control treatment. The cornerstones of ...