UNLABELLED Measurement of arterial input function is a restrictive aspect for quantitative (18)F-FDG PET studies in rodents because of their small total blood volume and the related difficulties in withdrawing blood. METHODS In the present study, we took advantage of the high spatial resolution of a recent dedicated small-animal scanner to extract the input function from the (18)F-FDG PET ima...

Measurement of a High-Temporal Resolution Arterial Input Function from MR Projections: Extension to Radial Acquisition to Compensate for Local Tissue Enhancement Jen Moroz, Stefan A Reinsberg, and Piotr Kozlowski Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, Radiology, UBC, University of British Columbia, BC, Canada, UBC MRI Research Centre, University of British...

UNLABELLED Small-animal PET provides the opportunity to image brain activation during behavioral tasks in animal models of human conditions. The present studies aimed to simplify behavioral imaging procedures without a loss of quantitation by using an intraperitoneal route of administration (no cannulation, no anesthesia) and using a standardized uptake value (SUV) to reduce scan duration. ME...

Evaluation of blood supply of different organs relies on labeling blood with a suitable tracer. The tracer kinetics is linear: Tracer concentration at an observation site is a linear response to an input somewhere upstream the arterial flow. The corresponding impulse response functions are currently treated empirically without incorporating the relation to the vascular morphology of an organ. I...

BACKGROUND AND PURPOSE The optimal TE must be calculated to minimize the variance in CBV measurements made with DSC MR imaging. Simulations can be used to determine the influence of the TE on CBV, but they may not adequately recapitulate the in vivo heterogeneity of precontrast T2*, contrast agent kinetics, and the biophysical basis of contrast agent-induced T2* changes. The purpose of this stu...