نتایج جستجو برای: hpmc k4m
تعداد نتایج: 1352 فیلتر نتایج به سال:
سابقه و هدف: در ﻣﯿﺎن اﻧﻮاع روشﻫﺎ ﺟﻬﺖ ﮐﺎﻫﺶ ﺟﺬب روﻏﻦ در ﺳﺮخﮐﻦ، اﺳﺘﻔﺎده از هیدروکلوئیدها یک روش مؤثر ﺑﻮده اﺳﺖ. در ﺗﺤﻘﯿﻖ ﺣﺎﺿﺮ اثر افزودن هیدروکسی پروپیل متیل سلولز (HPMC) در تهیه میگوی سوخاری در کاهش جذب روغن، حفظ رطوبت، میزان جذب لعاب، بازدهی محصول و خصوصیات حسی آن ﻣﻮرد ﻣﻄﺎﻟﻌﻪ ﻗﺮار ﮔﺮﻓﺖ. مواد و روشها: در این بررسی از 4 تیمار شاهد (بدون HPMC)، تیمار 1 (2% HPMC در آرد اولیه)، تیمار 2 (2% HPMC در ...
PURPOSE To compare the efficacy and safety of 0.3% hydroxypropyl methylcellulose/dextran (HPMC/dextran) and 0.18% sodium hyaluronate (SH) in the treatment of ocular surface disease in patients using antiglaucoma drugs containing preservatives. METHODS This was a double-blind, randomized, parallel-group study in 70 glaucoma patients with Ocular Surface Disease Index (OSDI) score greater than 2...
The present paper investigates the rheological properties of silated hydroxypropylmethylcellulose (Si-HPMC) biohydrogel used for biomaterials and tissue engineering applications. The general property of this modified cellulose ether is the occurrence of self-hardening due to silanol condensation subsequent to a decrease in pH (from 12.4 to nearly 7.4). The behavior of unsterilized and sterilize...
Purpose: To formulate mucoadhesive chlorhexidine tablets and evaluate their drug release characteristics and mechanism. Methods: Chlorhexidine buccal adhesive tablets were prepared by direct compression using a blend of hydroxypropyl methylcellulose (HPMC) and chitosan as the bioadhesive polymers. Their dissolution properties were assessed according to USP 24 (paddle method). In order to determ...
The purpose of this work was to study the effect of various permeation enhancers on the permeation of salbutamol sulphate (SS) buccal patches through buccal mucosa in order to improve the bioavailability by avoiding the first pass metabolism in the liver and possibly in the gut wall and also achieve a better therapeutic effect. The influence of various permeation enhancers, such as dimethyl sul...
Purpose: To utilize hydroxybutyl-β-cyclodextrin (HB-β-CD) and polyvinyl pyrrolidone (PVP) for the enhancement of the transdermal delivery of glimepiride (GMD). Methods: Matrix-type transdermal patches containing GMD, drug coprecipitate or its inclusion complex were prepared using different gelling agents, viz, hydroxypropyl methylcellulose (HPMC), hydroxypropyl cellulose (HPC), carbopol and chi...
PURPOSE To investigate the suitability of an SCMC (sodium carboxymethyl cellulose/polyethylene glycol 400/carbopol 934P) and an HPMC (hydroxypropylmethyl cellulose/polyethylene glycol 400/carbopol 934P) films as drug vehicle for buccal delivery. METHODS The mechanical and in vitro bioadhesive strength properties of the films were investigated using texture analyzer equipment, while swelling b...
During the dissolution of cocrystal particles, solution-mediated phase transformation (SMPT) can occur either on particle surface (PS-SMPT) or in bulk solution (BP-SMPT). In this study, we compared effect various polymers PS-SMPT and BP-SMPT for first time using carbamazepine saccharine (CBZ-SAC) as a model drug. Polyethylene glycol 6000 (PEG), polyvinylpyrrolidone K-30 (PVP), hydroxypropyl met...
Background and purpose: One of the methods of preparing controlled-release dosage forms is the incorporation of drug in a matrix containing a hydrophilic rate-controlling polymer. Drug-polymer ratio, drug particle size and HPMC particle size have been identified as modifiers of drug release. This study evaluated the relationship and influence of formulation factors such as drug-HPMC ratio and p...
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