Irisin is mainly released from skeletal muscle (myocytes) and promotes thermogenesis by browning of the white adipose tissue. Although exercise has been shown to increase irisin concentration in blood and myocytes via up-regulation peroxisome proliferator receptor γ coactivator-1α (PGC-1α) expression, the influence of exercise intensity on irisin secretion remains unclear. Therefore, we determi...

Background: Anabolic-androgenic steroids are used at high doses by athletes for improving athletic ability, physical appearance and muscle mass. Unfortunately, the abuse of these agents has significantly increased. It has been established that exercise and high doses of anabolic-androgenic steroids may influence the hypothalamic- pituitary-testis axis, which can in turn affect testicular apopto...

The purpose of the present study was to comprehensively examine oxygen consumption (VO(2)) kinetics during running and cycling through mathematical modeling of the breath-by-breath gas exchange responses to moderate and heavy exercise. After determination of the lactate threshold (LT) and maximal oxygen consumption (VO(2 max)) in both cycling and running exercise, seven subjects (age 26.6 +/- 5...

Amyotrophic lateral sclerosis (ALS) is characterized by selective and progressive degeneration of motoneurons (MNs). Although the etiology of the disease is unknown, glutamate toxicity and reac-tive oxygen species toxicity have been strongly implicated in ALS pathophysiol-ogy, Training exercise has been proposed to provide a beneficial therapy during the early or late stages of ALS (Pinto et al...

In recent years there has been considerable interest in the effects of locomotor activity on respiratory gas exchange and acid-base balance in the Crustacea (reviewed by Herreid, 1981; McMahon, 1981; McMahon & Wilkens, 1983). However, the partitioning of energy metabolism between aerobic and anaerobic pathways during crustacean locomotion is still poorly understood (Herreid, 1981; Full & Herrei...

OBJECTIVE The present study aims to explore the effect of zinc supplementation on lipid peroxidation and lactate levels in rats having diabetes induced by streptozotocin and subjected to acute swimming exercise. METHOD A total of 80 adult male rats of Sprague-Dawley type were equally allocated to 8 groups: Group 1, general control. Group 2, zinc-supplemented group. Group 3, zinc-supplemented,...

The aim of the present study is to understand the basic relationship between swimming exercise and natural course of epilepsy in animals by performing an electrophysiological study. For this purpose, male Wistar rats were submitted to daily swimming exercise program of three different durations. Animals were swim-exercised for 90 days with either 15 minutes, 30 minutes or 60 minutes/day. Therea...

introduction: previous studies indicate that exercise influences cognitive function. nevertheless, considering that exercise in animal study can be voluntary, or forced, effects of exercise (specially forced exercise) on learning and memory abides as a matter of controversy. the present study aimed to investigate the effects of treadmill exercise on ltp in the dentate gyrus of rats. methods: th...