Herpes simplex virus type 1 (HSV-1) with a worldwide distribution has been reported in all human populations, resulting in a clinical spectrum of infections. Although HSV type 2 (HSV-2) is known as the most common cause of genital herpes, an increasing number of cases with genital herpes are caused by HSV-1. The present study aimed to discuss the changes in the epidemiology of HSV-1 infection i...

Objective(s): Oncolytic Herpes simplex virus type 1 (HSV-1) has emerged as a promising strategy for cancer therapy. However, development of novel oncolytic mutants has remained a major challenge owing to low efficiency of conventional genome editing methods. Recently, CRISPR-Cas9 has revolutionized genome editing.Materials and Methods: I...

Emergence of drug resistance and adverse effects often affect the efficacy nucleoside analogues in therapy Herpes simplex type 1 (HSV-1) 2 (HSV-2) infections. Host-targeting antivirals could therefore be considered as an alternative or complementary strategy management HSV To contribute to this advancement, here we report on ability a new generation inhibitor key cellular enzyme de novo pyrimid...

Background Researching people with herpes simplex virus (HSV) is challenging because of poor data quality, low user engagement, and concerns around stigma anonymity. Objective This project aimed to improve collection for a real-world HSV registry by identifying predictors infection selecting limited number relevant questions ask new users determine their level risk. Methods The US National Heal...

Abstract Viruses closely related to human pathogens can reveal the origins of infectious diseases. Human herpes simplexvirus type 1 (HSV-1) and 2 (HSV-2) are hypothesized have arisen via host-virus codivergence cross-species transmission. We report discovery novel simplexviruses during a large-scale screening fecal samples from wild gorillas, bonobos, chimpanzees. Phylogenetic analysis indicate...

background herpes simplex virus type 1 and type 2 (hsv-1 and hsv-2) are common infectious agents worldwide. data on prevalence of hsv-1 and hsv-2 infections are limited in asia, especially in iran. our study aimed on determination of seroepidemiology of hsv-1 and hsv-2 infections in asymptomatic healthy students of islamic azad university of kazeroun, fars province, southwest of iran. patients ...

Herpes simplex virus type 1 (HSV-1) causes a lifelong latent infection with an estimated global prevalence of 66%. Primary and recurrent HSV infections are characterized by tingling sensation, followed eruption vesicles, which can cause painful erosions. Commonly used antiviral drugs against nucleoside analogues including acyclovir (ACV), famciclovir, valacyclovir. Although these reduce morbidi...