Polymorphisms in the cytochrome P (CYP) 450 family may cause adverse drug responses in individuals. Cytochrome P450 2C19 (CYP2C19) is a member of the CYP family, where the presence of the 681 G>A, 636 G>A and 806 C>T polymorphisms result in the CYP2C19*2, CYP2C19*3 and CYP2C19*17 alleles, respectively. In the current study, the frequency of the CYP2C19*2, CYP2C19*3 and CYP2C19*17 alleles in an ...

normal 0 false false false en-us x-none fa microsoftinternetexplorer4 aim : the purpose of this study was to determine the relationship of rs4444903 (egf+61a/g) snp genotype with colorectal cancer and tumor stage in an iranian population. background : epidermal growth factor ( egf ) is one of the important proteins that determine survival of cells. egf binds to its receptor on the cell surface ...

Genetic improvement programs may improve disease resistance in animal production. The best-characterized genetic control of disease resistance and immune response in animals is the one associated with the Major Histocompatibility Complex (MHC). The ovine lymphocyte antigenof DRB1 gene encodes cell surface glycoproteins that initiate immune responses by presenting processed antigenic peptides to...

The purpose of the study was to detect the AluI and DdeI polymorphisms within POU1F1 gene exon 6 and 3'UTR region in Turkish sheep breeds, and their association with milk productive traits. Jugular blood samples were collected from 50 Sakiz, 50 White Karaman, and 50 Awassi sheep using EDTA as an anticoagulant. PCR-RFLP and sequencing analysis were performed to investigate possible polymorphisms...

background: ghezel sheep are highly prolific and one of the local sheep breeds in iran and turkey. growth differentiation factor-9 (gdf9) gene has been found to be essential for growth and differentiation of early ovarian follicles. novel mutations in gdf9 have been associated with increased ovulation rates and high litter sizes in heterozygous carriers. therefore, fecundity gene for gdf9 (fecg...

Agricultural sector accounts for about 1/3 of the Iranian GDP and 1/4 of the country workforce. More than 90% of the Iranian food requirements are produced in the country. Animal agriculture covers over 40% of the agricultural activities. More than 57% of the available animal units in the country are sheep and goats. Desertification, deforestation, water shortage, erosion, low efficiency and ou...

The diacylglycerol acyltransferase 1 gene (DGAT1) was identified as a strong candidate gene affecting mutton quality traits in sheep. Single nucleotide polymorphism creates a single base mutation (C to T) in AGCT site of endonuclease AluI. DGAT1 is one of the candidate genes to improve carcass characteristics in feedlot animals. In order to study area T487C in exon 17 of the DGAT1 polymorphism,...

The major histocompatibility complex (MHC) plays a central role in the control of disease resistance and immune response. Extensive genetic diversity in MHC genes provides a valuable source for genetic improvement, via selection, in many domestic animals. Exon 2 of the class II MHC, termed Ovar-DRB1 in domestic sheep (Ovis aries), has been suggested as important disease resistance and immune re...

the major histocompatibility complex (mhc) plays a central role in the control of disease resistance and immune response. extensive genetic diversity in mhc genes provides a valuable source for genetic improvement, via selection, in many domestic animals. exon 2 of the class ii mhc, termed ovar-drb1 in domestic sheep (ovis aries), has been suggested as important disease resistance and immune re...