Pathologic mechanisms in cochleae immediately following the onset of noise-induced hearing loss (NIHL) remain unclear. In this study, mice were exposed to 120 dB octave band noise for 2 h induce NIHL. Three hours after exposure, expression levels whole mouse genome analyzed by RNA-seq and DNA microarray. Differentially expressed genes (DEGs) exhibiting >2-fold upregulation or downregulation noi...

m-miR-184 (mutant miR-184, r.57c > u) appears in familial hereditary ocular diseases, including keratoconus, cataracts, EDICT (endothelial dystrophy, iris hypoplasia, congenital cataract, and stromal thinning) syndrome, severe keratoconus, and non-ectatic corneal thinning. The biological function of m-miR-184 in these ocular diseases remains unclear. With the emergence of high-throughput sequen...

Gonadotropin-releasing hormone (GnRH) neurons play a key role in the central regulation of reproduction. In proestrous female mice, estradiol triggers the pre-ovulatory GnRH surge, however, its impact on the expression of neurotransmitter receptor genes in GnRH neurons has not been explored yet. We hypothesized that proestrus is accompanied by substantial changes in the expression profile of ge...

s | 9 Purpose: We aimed to investigate the genetics of antidepressant response in patients with obsessive-compulsive disorder (OCD) in two ethnic groups. Hypothesis: We postulated that different genetic variations across known OCD candidate genes may predict antidepressant response in OCD patients with different ethnic background. Method: We examined two independent and ethnically different OCD...

s | 9 Purpose: We aimed to investigate the genetics of antidepressant response in patients with obsessive-compulsive disorder (OCD) in two ethnic groups. Hypothesis: We postulated that different genetic variations across known OCD candidate genes may predict antidepressant response in OCD patients with different ethnic background. Method: We examined two independent and ethnically different OCD...

s | 9 Purpose: We aimed to investigate the genetics of antidepressant response in patients with obsessive-compulsive disorder (OCD) in two ethnic groups. Hypothesis: We postulated that different genetic variations across known OCD candidate genes may predict antidepressant response in OCD patients with different ethnic background. Method: We examined two independent and ethnically different OCD...