BACKGROUND AND OBJECTIVE Notch1 belongs to the Notch family of transmembrane receptors and plays an important role in tumor cell proliferation and apoptosis. Notch1 affects chemosensitivity of tumors. However, its correlation to cisplatin (DDP)-sensitivity of head and neck squamous cell carcinoma is unclear. This study was to identify the expression of Notch1 in head and neck squamous cell carc...

EDUCATIONAL OBJECTIVE At the conclusion of this presentation, the participants should be familiar with the clinical and pathologic features of collision tumors in the head and neck. OBJECTIVES Present a case of collision tumor of the head and neck consisting of metastatic squamous cell carcinoma and B-cell lymphoma. Review the literature on collision tumors of the head and neck. STUDY DESIG...

The optimal fractionation schedule for radiotherapy of head and neck cancer has been controversial. The objective of this randomized trial was to test the efficacy of hyperfractionation vs. standard fractionation. Patients with squamous cell carcinoma of head and neck organs were randomly assigned to receive radiotherapy delivered with A) standard fractionation at 2 Gy/fraction/day, 5 days...

Introduction HPV as a risk factor of head and neck squamous cell carcinoma (HNSCC) is gaining increasing importance. Tobacco alcohol abuse already known to induce the occurrence HNSCC. However, awareness an independent vaccination preventive measure not widespread among general population.

background: although the imbalance of cytokines in head and neck squamous cell carcinoma (hnscc) is well known, there is scarce data regarding its occurrence during dysplasia, before the malignant transformation. objective: to determine whether laryngeal dysplasia patients show a different cytokine profile than patients with cancer and healthy controls. methods: seventeen newly diagnosed, untre...

Introduction: Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers in the world. Extra- and intra-cellular high-mobility motor box 1 (HMGB1) proteins are invovled in the pathogenesis and prognosis of cancer. Regarding this, the present study was conducted with the aim of investigating the expression of HMGB1 protein and mRNA levels in the blood, tumor tissue, and mar...

Background and purpose: Cancer is highly prevalent in modern societies and approximately one in three or four people is diagnosed with cancer. Oral cancer is one of the 10 primary causes of mortality due to late detection for many reasons, including being asymptomatic in initial stages, clinical presentation similar to other lesions, and variation in clinical manifestations. This study aimed at...

For citation purposes: Lanzer M, Zemann W, Lübbers T, Kruse A, Reinisch S. Do patients with oral and oropharyngeal squamous cell carcinoma benefit from elective contralateral neck dissection? A long-term analysis. Head Neck Oncol. 2012 Oct 31;4(3):70. Licensee OA Publishing London 2012. Creative Commons Attribution License (CC-BY) Abstract Objectives Oral and oropharyngeal squamous cell carcino...

background: although color doppler ultrasonography (cdus) is useful in the diagnosis of various diseases of the head and neck, flow signals in oral malignant masses are less studied; hence the present study assesses the usefulness of color doppler ultrasonography in quantifying oral squamous cell carcinoma (oscc) vascularization. in addition, we determine the hemodynamic parameters by spectral ...