Abstract Background Findings and limitations of previous studies on persistent organic pollutants (POPs) pancreatic cancer risk support conducting further research in prospective cohorts. Objective To investigate the association between plasma concentrations selected POPs risk. Methods Prospective case-control study nested within EPIC cohort. Participants were 513 cases 1020 matched controls. C...

INTRODUCTION Free or low-cost HIV testing, condoms, and lubricants are foundational HIV prevention strategies, yet are often inaccessible for men who have sex with men (MSM). In the global context of stigma and poor healthcare access, transgender (trans) MSM may face additional barriers to HIV prevention services. Drawing on data from a global survey of MSM, we aimed to describe perceived acces...

FK506 binding proteins (FKBPs) in cells are known as immunophilins. We have identified and characterized a cDNA encoding an endoplasmic reticulum (ER) immunophilin, FKBP23, from pig liver by nested PCR. The predicted amino acid sequence of pig FKBP23 shows high identity to those of human FKBP23 and mouse FKBP23. It possesses a conserved FKBP-type peptidylprolyl cis-trans isomerase (PPIase) doma...

purpose: to ascertain whether the use of nested-pcr (nested polymerase chain reaction) technique leads to more rapid and accurate diagnosis of bacterial endophthalmitis. methods: the aqueous humor and vitreous samples of 24 eyes of 24 patients with bacterial endophthalmitis were evaluated by microscopy, diagnostic aerobic culture, and nested- pcr to detect the infectious agent. results: aerobic...

The HDV ribozyme is an RNA enzyme from the human pathogenic hepatitis delta virus (HDV) that has recently also been identified in the human genome. It folds into a compact, nested double-pseudoknot. We examined here the functional relevance of the capping loop L4 and the helical crossover J1/2, which tightly interlace the two helical stacks of the ribozyme. Peripheral structural elements such a...

Objective: Studies elucidating the importance of IL (interleukin)-6 trans-signaling associated with risk future myocardial infarction (MI) are scarce. Additionally, whether elevation in IL-6 explains part association between traditional factors and MI has not been explored. Approach Results: We conducted a nested case-control study including total 584 participants (292 cases 292 controls) from ...