Background: Prolactin (PRL) appears to play a role in the pathogenesis of autoimmune diseases. Limited evidence showed an association between serum PRL levels and the activity of pemphigus vulgaris (PV). This study intends to determine PRL level changes in pemphigus patients during therapy and its correlation with disease type and severity. Methods: In this cohort study, we measured serum PRL l...

At present, there is no consensus about the clinical criteria that define disease severity of pemphigus. During recent years several scoring systems have been introduced which mainly compare inter-individual differences in disease activity. It thus remains a challenge to reflect the disease activity of individual patients by a standardised scoring system. Due to the remarkable clinical variabil...

IMPORTANCE The main component of the first-line treatment of pemphigus vulgaris is high doses of systemic corticosteroids, but adverse effects of these drugs are frequent and sometimes severe. Rituximab has shown effectiveness as a corticosteroid-sparing agent or in case of relapse. To our knowledge, the effectiveness of rituximab as a first-line treatment without systemic corticosteroids has n...

Background Some studies emphasise the relationship between herpes simplex virus (HSV) and pemphigus. Although possible role of HSV in pathogenesis pemphigus severity disease is obscure, we aimed to evaluate presence viruses (HSV 1/2) oral lesions patients with vulgaris also assess its association types lesions. Methods A retrospective study was conducted on collected data form collecting paraff...

In pemphigus, autoantibodies form against desmoglein. Desmoglein forms the "glue" that attaches adjacent epidermal cells via attachment points called desmosomes. When autoantibodies attack desmogleins, the cells become separated from each other and the epidermis becomes "unglued", a phenomenon called acantholysis. This causes blisters that slough off and turn into sores. In some cases, these bl...