Traumatic brain injury is a serious global health problem with irreversible high morbidity and disability and Because of its unknown pathophysiological mechanisms, efficient therapeutic approaches to improve the poor outcome and long-term impairment of behavioral function are still remains lacking. The microglial cells are the resident macrophage cells of the brain and have M1/M2 phenotype, for...

Background: Bone marrow stromal cells (BMSC) are used as a source for cell therapy in different model for neurological disorder such as stroke and spinal cord injury. However, the transdifferentiation of BMSC into cholinergic phenotype requires more investigation. Methods: BMSC were isolated from adult rats, pre-induced with β-mercaptoethanol (BME) and followed by nerve growth factor (NGF) indu...

Background and Aims: Rhnull, with an estimated incidence of one per 6,000,000 individuals, is an extremely rare disorder with an autosomal recessive pattern of inheritance that is more common in societies with a high rate of consanguinity. Materials and Methods: In this study, we report the first case with Rhnull, a blood group phenotype in southeast Iran, which was diagnosed during pretransf...

Traumatic brain injury is a serious global health problem with irreversible high morbidity and disability and Because of its unknown pathophysiological mechanisms, efficient therapeutic approaches to improve the poor outcome and long-term impairment of behavioral function are still remains lacking. The microglial cells are the resident macrophage cells of the brain and have M1/M2 phenotype, for...

the broad goal of this research was to examine the nature of the melanocortin receptor 1 (mc1r) locus on the coat color phenotype of seven goat breeds with different color coat. blood samples were collected from five iranian indigenous (khalkhal, markhor, naeini, najdi and tali) and two exotic (cashmere and saanen) goat breeds. polymerase chain reaction restriction fragment length polymorphism ...

autoselection is a kind of natural selection, that occurs in reproductive traits by inequality of offspring generation and therefore by virtue of the nature of its genes transmission to next generations. in this study, the effects of autoselection on heritability and selection response in reproductive traits by using univariate stochastic computer simulation in artificial selected and unselecte...