Any Bayesian analysis involves combining information represented through different model components, and when sources of are in conflict it is important to detect this. Here we consider checking for prior-data models by expanding the prior used into a larger family priors, considering marginal likelihood score statistic expansion parameter. Consideration expansions can be informative about natu...

We report a case of metastatic castration-resistant prostate cancer, who received prior treatment with docetaxel and was then given cabazitaxel as salvage therapy. The patient was monitored by prostate-specific antigen doubling time and prostate-specific antigen absolute value. The prostate-specific antigen doubling time was found to be a good response predictor in the patient.

OBJECTIVE To characterize the impact of intermittent use of triple drug antiretroviral therapy on survival. DESIGN, SETTING AND PARTICIPANTS Population-based analysis of 1282 antiretroviral therapy naive HIV-positive individuals aged 18 years and older in British Columbia who started triple-combination therapy between August 1996 and December 1999. Therapy use was estimated by dividing the nu...

BACKGROUND Paclitaxel and vinorelbine are active in advanced breast cancer pretreated with anthracyclines We therefore conducted a phase II study to define the toxicity and activity of paclitaxel and vinorelbine administered in combination. PATIENTS AND METHODS Our patient population consisted of 37 patients with metastatic breast cancer, 35 of whom had received prior chemotherapy including a...