Background & Aims: Change in visual experience impairs circadian rhythms. In this study, The effects of visual deprivation during critical period of brain development and melatonin intake on synaptic plasticity of hippocampal CA1 neurons were evaluated. Methods: This experimental study was done on male rats kept in standard 12 hour light/dark condition (L...

Glucose provides an essential nutrient source that supports glycolysis and the hexosamine biosynthesis pathway (HBP) to maintain tumour cell growth and survival. Here we investigated if short-term glucose deprivation specifically modulates the phosphatidylinositol 3-kinase/protein kinase B (PI3K/PKB) cell survival pathway. Insulin-stimulated PKB activation was strongly abrogated in the absence ...

Previous studies have shown that caffeine has beneficial effects on cognitive impairment in sleep deprived male rats. Therefore in the present study, we examined the effects of chronic caffeine administration on learning and memory impairments induced by sleep deprivation (SD) in the intact and ovarectomized (OVX) female rats. Two sets of animals including intact and OVX were randomly recruited...

the objective of this study was to evaluate the impact of short-term starvation and re-feeding on oxidative stress in mesopotamichthys sharpeyi (günther, 1874). after two weeks adaptation to new conditions, a total number of 270 fingerlings were distributed into nine 300-l fiberglass tanks, equipped with aeration system in three treatments including 4, 8 and 16 days starvation (each in 3 replic...

sleep deprivation (sd) increases the risk of human-error related accidents and a major cause of motor vehicle accidents. the overall prevalence of insufficient sleep in adults has been estimated at 20%. according to a comprehensive study prevalence of daytime sleepiness, among young adults (age 21 to 30 years), the average nocturnal sleep time during weekdays was 6.7 hours and on weekends was 7...

Postnatal sensory experience plays a significant role in the maturation and synaptic stabilization of sensory cortices, such as the primary auditory cortex (A1). Here, we examined the effects of patterned sound deprivation (by rearing in continuous white noise, WN) during early postnatal life on short- and long-term plasticity of adult male rats using an in vivo preparation (urethane anesthesia...

BACKGROUND An increased awareness of prostate cancer has led to a rise in the detection of this disease at a clinically localized stage at presentation. This article discusses the role of neoadjuvant hormonal ablation at this earlier stage to decrease tumor bulk and thus enhance survival. METHODS Outcomes from each primary modality for localized treatment of prostate cancer with and without n...

Delirium occurs frequently in critically ill patients and has been associated with both short-term and long-term consequences. Efforts to decrease delirium prevalence have been directed at identifying and modifying its risk factors. One potentially modifiable risk factor is sleep deprivation. Critically ill patients are known to experience poor sleep quality with severe sleep fragmentation and ...