Evidence Three large international RCTs in females aged 15 to 26 used modified intention-to-treat analysis (including patients with positive test results for HPV at baseline) for all HPV lesions.1-4 • Quadrivalent vaccine (HPV 6, 11, 16, and 18): -FUTURE 1 trial1 following 5455 women for 4 years found decreased external genital lesions (3.8% vs 5.7% [placebo]; number needed to vaccinate [NNV] =...

Rats with normal renal function (Experiment 1, n = 12) and uninephrectomized (1/2Nx) rats (Experiment 2, n = 12) were fed diets with normal P (NP) and either normal (NF) or high fat (HF). Rats with intact renal function (Experiment 3, n = 12) were also fed NF or HF diets with high P (HP). Additionally, uremic (5/6Nx) rats (n = 16) were fed HP diets with NF or HF. Feeding the HF diets resulted i...

OBJECTIVES Major vascular injury is a leading cause of potentially preventable hemorrhagic death in modern combat operations. An optimal resuscitation approach for military trauma should offer both rapid hemorrhage control and early reversal of metabolic derangements. The objective of this report is to establish the use and effectiveness of a damage control resuscitation (DCR) strategy in the s...

Young adults with a family history of hypertension (+FH) have increased risk of developing hypertension. Furthermore, the blood pressure (BP) response to sympathoexcitatory stimuli in young adults can predict the future development of hypertension. Therefore, we hypothesized young women with a +FH would have exaggerated cardiovascular and sympathetic reactivity compared with young women without...

Greaney JL, Matthews EL, Wenner MM. Sympathetic reactivity in young women with a family history of hypertension. Am J Physiol Heart Circ Physiol 308: H816–H822, 2015. First published February 13, 2015; doi:10.1152/ajpheart.00867.2014.—Young adults with a family history of hypertension ( FH) have increased risk of developing hypertension. Furthermore, the blood pressure (BP) response to sympatho...

background: l-carnitine may prevent the incidence of aki by its antioxidant effects and improving circulation in ischemic conditions. the goal of this trial was to evaluate the impact of l-carnitine on contrast-induced nephropathy in patients undergoing elective pci. methods: totally, the patients were randomly allocated to 2 groups. the treatment group received 1 g of l-carnitine orally 3 time...